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dc.contributor.authorAguirre, Adrián
dc.contributor.authorGonzalez, Arlyng
dc.contributor.authorNavarro, Melba
dc.contributor.authorCastaño Linares, Óscar
dc.contributor.authorPlanell Estany, Josep Anton
dc.contributor.authorEngel López, Elisabeth
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
dc.contributor.otherInstitut de Bioenginyeria de Catalunya
dc.identifier.citationAguirre, A. [et al.]. Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis. "European cells and materials", Setembre 2012, vol. 24, p. 90-106.
dc.description.abstractSmart biomaterials play a key role when aiming at successful tissue repair by means of regenerative medicine approaches, and are expected to contain chemical as well as mechanical cues that will guide the regenerative process. Recent advances in the understanding of stem cell biology and mechanosensing have shed new light onto the importance of the local microenvironment in determining cell fate. Herein we report the biological properties of a bioactive, biodegradable calcium phosphate glass/polylactic acid composite biomaterial that promotes bone marrowderived endothelial progenitor cell (EPC) mobilisation, differentiation and angiogenesis through the creation of a controlled bone healing-like microenvironment. The angiogenic response is triggered by biochemical and mechanical cues provided by the composite, which activate two synergistic cell signalling pathways: a biochemical one mediated by the calcium-sensing receptor and a mechanosensitive one regulated by non-muscle myosin II contraction. Together, these signals promote a synergistic response by activating EPCs-mediated VEGF and VEGFR-2 synthesis, which in turn promote progenitor cell homing, differentiation and tubulogenesis. These findings highlight the importance of controlling microenvironmental cues for stem/progenitor cell tissue engineering and offer exciting new therapeutical opportunities for biomaterialbased vascularisation approaches and clinical applications
dc.format.extent17 p.
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Medicina interna
dc.subject.lcshCalcium phosphate
dc.subject.lcshBiomedical materials
dc.subject.otherCalcium phosphate glass composite
dc.subject.othersmart biomaterial
dc.subject.otherendothelial progenitor cell
dc.subject.othercalcium-sensing receptor
dc.titleControl of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis
dc.subject.lemacEnginyeria biomèdica
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.rights.accessOpen Access
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/FP7/214402/EU/Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Enginering/ANGIOSCAFF
local.citation.authorAguirre, A.; Gonzalez, A.; Navarro, M.; Castaño, O.; Planell, J.; Engel, E.
local.citation.publicationNameEuropean cells and materials

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