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Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis

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hdl:2117/19725

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Aguirre, Adrián
Gonzalez, Arlyng
Navarro, Melba
Castaño Linares, ÓscarMés informació
Planell Estany, Josep AntonMés informacióMés informacióMés informació
Engel López, ElisabethMés informacióMés informacióMés informació
Document typeArticle
Defense date2012-09
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
ProjectANGIOSCAFF - Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Enginering (EC-FP7-214402)
Abstract
Smart biomaterials play a key role when aiming at successful tissue repair by means of regenerative medicine approaches, and are expected to contain chemical as well as mechanical cues that will guide the regenerative process. Recent advances in the understanding of stem cell biology and mechanosensing have shed new light onto the importance of the local microenvironment in determining cell fate. Herein we report the biological properties of a bioactive, biodegradable calcium phosphate glass/polylactic acid composite biomaterial that promotes bone marrowderived endothelial progenitor cell (EPC) mobilisation, differentiation and angiogenesis through the creation of a controlled bone healing-like microenvironment. The angiogenic response is triggered by biochemical and mechanical cues provided by the composite, which activate two synergistic cell signalling pathways: a biochemical one mediated by the calcium-sensing receptor and a mechanosensitive one regulated by non-muscle myosin II contraction. Together, these signals promote a synergistic response by activating EPCs-mediated VEGF and VEGFR-2 synthesis, which in turn promote progenitor cell homing, differentiation and tubulogenesis. These findings highlight the importance of controlling microenvironmental cues for stem/progenitor cell tissue engineering and offer exciting new therapeutical opportunities for biomaterialbased vascularisation approaches and clinical applications
CitationAguirre, A. [et al.]. Control of microenvironmental cues with a smart biomaterial composite promotes endothelial progenitor cell angiogenesis. "European cells and materials", Setembre 2012, vol. 24, p. 90-106. 
URIhttp://hdl.handle.net/2117/19725
ISSN1473-2262
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  • IBEC - Institute for Bioengineering of Catalonia - Articles de revista [50]
  • Departament de Ciència dels Materials i Enginyeria Metal·lúrgica - Articles de revista [960]
  • BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [484]
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