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dc.contributor.authorBarba, Elisabeth
dc.contributor.authorQuiroga, Santi
dc.contributor.authorAccarino, Anna
dc.contributor.authorMonclús Lahoya, Eva
dc.contributor.authorMalagelada, C
dc.contributor.authorBurri, E
dc.contributor.authorNavazo Álvaro, Isabel
dc.contributor.authorMalagelada, J
dc.contributor.authorAzpiroz, Fernando
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Llenguatges i Sistemes Informàtics
dc.identifier.citationBarba, E. [et al.]. Mechanisms of abdominal distension in severe intestinal dysmotility: abdomino-thoracic response to gut retention. "Neurogastroenterology and motility", 2013, vol. 25, núm. 6, p. e389-e394.
dc.description.abstractBACKGROUND: We previously showed that abdominal distension in patients with functional gut disorders is due to a paradoxical diaphragmatic contraction without major increment in intraabdominal volume. Our aim was to characterize the pattern of gas retention and the abdomino-thoracic mechanics associated with abdominal distension in patients with intestinal dysmotility. METHODS: In 15 patients with manometrically proven intestinal dysmotility, two abdominal CT scans were performed: one during basal conditions and other during an episode of severe abdominal distension. In 15 gender- and age-matched healthy controls, a basal scan was performed. KEY RESULTS: In basal conditions, patients exhibited more abdominal gas than healthy subjects, particularly in the small bowel, and the volume significantly increased during an episode of distension. During episodes of abdominal distension, the increase in abdominal content was associated with increased girth and antero-posterior abdominal diameter, as well as a cephalic displacement of the diaphragm, which reduced the height of the lung. The consequent reduction in the air volume of the lung was attenuated by an increase in the antero-posterior diameter of the chest. CONCLUSIONS & INFERENCES: Abdominal distension in patients with severe intestinal dysfunction is related to marked pooling of gut contents, particularly in the small bowel. This increase in content is accommodated within the abdominal cavity by a global and coordinated abdomino-phreno-thoracic response, involving an accommodative ascent of the diaphragm and a compensatory expansion of the chest wall.
dc.subjectÀrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica
dc.subject.lcshIntestinal diseases
dc.subject.otherabdominal bloating
dc.subject.otherabdominal distension
dc.subject.otherintestinal dysmotility
dc.subject.otherintestinal gas
dc.subject.otherintestinal pseudoobstruction
dc.titleMechanisms of abdominal distension in severe intestinal dysmotility: abdomino-thoracic response to gut retention
dc.subject.lemacIntestins -- Malalties
dc.contributor.groupUniversitat Politècnica de Catalunya. MOVING - Grup de Recerca en Modelatge, Interacció i Visualització en Realitat Virtual
dc.description.peerreviewedPeer Reviewed
dc.rights.accessRestricted access - author's decision
dc.description.versionPostprint (published version)
upcommons.citation.authorBarba, E.; Quiroga, S.; Accarino, A.; Monclús, E.; Malagelada, C.; Burri, E.; Navazo, I.; Malagelada, J.; Azpiroz, F.
upcommons.citation.publicationNameNeurogastroenterology and motility

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