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dc.contributor.authorOlmo Osuna, Cristian
dc.contributor.authorFranco García, María Lourdes
dc.contributor.authorValle Mendoza, Luis Javier del
dc.contributor.authorPuiggalí Bellalta, Jordi
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Polímers i Biopolímers
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2020-07-16T13:10:46Z
dc.date.available2020-07-16T13:10:46Z
dc.date.issued2020-04-29
dc.identifier.citationOlmo, C. [et al.]. Biodegradable polylactides scaffolds with pharmacological activity by means of ultrasound micromolding technology. "Applied sciences", 29 Abril 2020, vol. 10, núm. 9, p. 3106:1-3106:22.
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/2117/193045
dc.description.abstractUltrasound micromolding technology has been applied to get microporous polylactide scaffolds from the subsequent leaching of incorporated NaCl salts. A small amount of water-soluble polyethylene glycol (PEG) was required in order to improve the leaching process and get compact pieces with interconnected pores. Distribution of polymers in the processed specimens was quite homogeneous due to the small PEG content, although it was more concentrated in the regions close to the feeding channels due to its higher viscosity. Hydrophobic drugs like triclosan could be incorporated causing a minimum degradation during ultrasound processing and suffering an insignificant solubilization during the leaching step. Final scaffolds showed clear bactericide or bacteriostatic effects before and after 10 h of exposure. Cell proliferation of MDCK epithelial cells was higher for TCS loaded porous scaffolds (200%) than for unloaded samples (170%) and non-porous polylactide (PLA) specimens (100%, control). Micrographs showed the absence of non-inhibition areas in both the specimens and the container, confirming the biocompatibility of PLA specimens
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshChemical engineering
dc.subject.otherUltrasound micromolding
dc.subject.otherMicropieces
dc.subject.otherPolylactide
dc.subject.otherPorous scaffolds
dc.subject.otherSalt leaching
dc.subject.otherPolyethylene glycol
dc.subject.otherAntibacterial activity
dc.subject.otherDrug release
dc.subject.otherTriclosan
dc.subject.otherBiocompatibility
dc.titleBiodegradable polylactides scaffolds with pharmacological activity by means of ultrasound micromolding technology
dc.typeArticle
dc.subject.lemacEnginyeria química
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
dc.identifier.doi10.3390/app10093106
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/10/9/3106
dc.rights.accessOpen Access
local.identifier.drac28781752
dc.description.versionPostprint (published version)
local.citation.authorOlmo, C.; Franco, L.; del Valle, LJ.; Puiggali, J.
local.citation.publicationNameApplied sciences
local.citation.volume10
local.citation.number9
local.citation.startingPage3106:1
local.citation.endingPage3106:22


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain