Coupling fluid and solid domains in modeling drug transport within tumor
Visualitza/Obre
Estadístiques de LA Referencia / Recolecta
Inclou dades d'ús des de 2022
Cita com:
hdl:2117/191271
Tipus de documentText en actes de congrés
Data publicació2015
EditorCIMNE
Condicions d'accésAccés obert
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Abstract
Development of a feasible model for transport within complex vasculature network
and tissue remains a challenge. Such a model is particularly important when considering drug
transport within tumor environment. A drug used to cure the cancer is first transported
through blood vessels, then it attaches to the vessel endothelium and faces biological barriers
in the vessel wall to reach cancerous cells.
We have developed a model for convective-diffusive drug transport which is simple and
computationally efficient. One of the challenges was to couple fluid domain within blood
vessels and solid domain of the tumor microenvironment. We have introduced fictitious 1D
finite elements which appropriately take into account transport characteristics of the vessel
walls. These characteristics include leakage and permeability of the walls. In evaluating wall
permeability of a drug, we implemented our hierarchical multiscale methodology which
couples molecular dynamics (MD) and continuum FE model. A numerical homogenization
procedure was employed to obtain equivalent continuum transport parameters which account
for interaction on molecular level between drug and solid components of the wall
microstructure. Also, a possibility of using equivalent continuum transport models for
capillary beds is investigated in order to further simplify and increase efficiency for the
overall model of tumor.
As a numerical example, we calculate transport through a capillary bed to illustrate
applicability of our methodology.
ISBN978-84-943928-3-2
Fitxers | Descripció | Mida | Format | Visualitza |
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Coupled-2015_51 ... luid and solid domains.pdf | 556,7Kb | Visualitza/Obre |