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Biphasic calcium sulfate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications : in vitro studyAward-winning

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10.1088/1748-6041/5/2/025006
 
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Vlad, María Daniela
Valle Mendoza, Luis Javier delMés informacióMés informacióMés informació
Poeata, I.
López López, JoséMés informacióMés informacióMés informació
Torres Cámara, RicardoMés informacióMés informacióMés informació
Barraco Serra, MarcMés informació
Fernández Aguado, EnriqueMés informacióMés informacióMés informació
Document typeArticle
Defense date2010-03
Rights accessRestricted access - publisher's policy
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
In this study, the cytocompatibility of new ‘iron-modified/alpha-tricalcium phosphate (IM/α-TCP) and calcium sulfate dihydrate (CSD)’ bone cement (IM/α-TCP/CSD-BC) intended for spinal applications has been approached. The objective was to investigate by direct-contact osteoblast-like cell cultures (from 1 to 14 days) the in vitro cell adhesion, proliferation, morphology and cytoskeleton organization of MG-63 cells seeded onto the new cements. The results were as follows: (a) quantitative MTT-assay and scanning electron microscopy (SEM) showed that cell adhesion, proliferation and viability were not affected with time by the presence of iron in the cements; (b) double immunofluorescent labeling of F-actin and α-tubulin showed a dynamic interaction between the cell and its porous substrates sustaining the locomotion phenomenon on the cements’ surface, which favored the colonization, and confirming the biocompatibility of the experimental cements; (c) SEM-cell morphology and cytoskeleton observations also evidenced that MG-63 cells were able to adhere, to spread and to attain normal morphology on the new IM/α-TCP/CSD-BC which offered favorable substratum properties for osteoblast-like cells proliferation and differentiation in vitro. The results showed that these new iron-modified cement-like biomaterials have cytocompatible features of interest not only as possible spinal cancellous bone replacement biomaterial but also as bone tissue engineering scaffolds.
Description
Premi del "National University Research Council" del Ministeri d'Educació i Recerca de Romania, a autors romanesos per l'impacte de la seva recerca.
CitationVlad, M. [et al.]. Biphasic calcium sulfate dihydrate/iron-modified alpha-tricalcium phosphate bone cement for spinal applications : in vitro study. "Biomedical materials", Març 2010, vol. 5, núm. 2, p. 1-13. 
Award-winningAward-winning
URIhttp://hdl.handle.net/2117/19113
DOI10.1088/1748-6041/5/2/025006
ISSN1748-6041
Publisher versionhttp://iopscience.iop.org/1748-605X/5/2/025006/pdf/1748-605X_5_2_025006.pdf
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