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dc.contributor.authorÁlvarez Lacalle, Enrique
dc.contributor.authorRodríguez Cantalapiedra, Inma
dc.contributor.authorPeñaranda Ayllón, Angelina
dc.contributor.authorCinca, J.
dc.contributor.authorHove-Madsen, Leif
dc.contributor.authorEchebarría Domínguez, Blas
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física Aplicada
dc.date.accessioned2013-04-23T13:08:23Z
dc.date.available2013-04-23T13:08:23Z
dc.date.created2013-02-04
dc.date.issued2013-02-04
dc.identifier.citationAlvarez-Lacalle, E. [et al.]. Dependency of calcium alternans on Ryanodine Receptor Refractoriness. "PLoS One", 04 Febrer 2013, vol. 8, núm. 2.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/2117/18961
dc.description.abstractBackground Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium rele However, the relationship between calcium alternans and refractoriness of the SR calcium release channel (RyR2) Methodology/Principal Findings To investigate how ryanodine receptor (RyR2) refractoriness modulates calcium handling on a beat-to-beat basis u used a mathematical rabbit cardiomyocyte model to study the beat-to-beat calcium response as a function of RyR were constructed depicting the beat-to-beat response. When alternans was observed, a novel numerical clamping was caused by oscillations in SR calcium loading or by RyR2 refractoriness. Using this protocol, we identified regio loading or RyR2 refractoriness underlie the induction of calcium alternans, and we found that at the onset of altern inactivation rates of the RyR2, calcium alternans was caused by alternation in SR calcium loading, while at low act level of available RyR2s. Conclusions/Significance We have mapped cardiomyocyte beat-to-beat responses as a function of RyR2 activation and inactivation, identify refractoriness underlie the induction of calcium alternans. A corollary of this work is that RyR2 refractoriness due t of calcium alternans even when alternation in SR calcium load is present.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut
dc.subject.lcshRyanodine--Receptors
dc.titleDependency of calcium alternans on Ryanodine Receptor Refractoriness
dc.typeArticle
dc.subject.lemacReceptors (Biologia)
dc.contributor.groupUniversitat Politècnica de Catalunya. NOLIN - Física No-Lineal i Sistemes Fora de l'Equilibri
dc.contributor.groupUniversitat Politècnica de Catalunya. GICITED - Grup Interdiciplinari de Ciència i Tecnologia en l'Edificació
dc.identifier.doi10.1371/journal.pone.0055042
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055042
dc.rights.accessOpen Access
local.identifier.drac11708942
dc.description.versionPostprint (published version)
local.citation.authorAlvarez-Lacalle, E.; Rodriguez, I.; Peñaranda, A.; Cinca, J.; Hove-Madsen, L.; Echebarria, B.
local.citation.publicationNamePLoS One
local.citation.volume8
local.citation.number2
dc.identifier.pmid23390511


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