Show simple item record

dc.contributor.authorFlemming, Sven
dc.contributor.authorFont Martínez, Francesc
dc.contributor.authorAlonso Muñoz, Sergio
dc.contributor.authorBeta, Carsten
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física
dc.date.accessioned2020-05-21T13:13:41Z
dc.date.issued2020-03-24
dc.identifier.citationFlemming, S. [et al.]. How cortical waves drive fission of motile cells. "Proceedings of the National Academy of Sciences of the United States of America", 24 Març 2020, vol. 117, núm. 12, p. 6330-6338.
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/2117/188542
dc.description.abstractCytokinesis—the division of a cell into two daughter cells—is a key step in cell growth and proliferation. It typically occurs in synchrony with the cell cycle to ensure that a complete copy of the genetic information is passed on to the next generation of daughter cells. In animal cells, cytokinesis commonly relies on an actomyosin contractile ring that drives equatorial furrowing and separation into the two daughter cells. However, also contractile ring-independent forms of cell division are known that depend on substrate-mediated traction forces. Here, we report evidence of an as yet unknown type of contractile ring-independent cytokinesis that we termed wave-mediated cytofission. It is driven by self-organized cortical actin waves that travel across the ventral membrane of oversized, multinucleated Dictyostelium discoideum cells. Upon collision with the cell border, waves may initiate the formation of protrusions that elongate and eventually pinch off to form separate daughter cells. They are composed of a stable elongated wave segment that is enclosed by a cell membrane and moves in a highly persistent fashion. We rationalize our observations based on a noisy excitable reaction–diffusion model in combination with a dynamic phase field to account for the cell shape and demonstrate that daughter cells emerging from wave-mediated cytofission exhibit a well-controlled size.
dc.format.extent9 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Física
dc.subject.lcshReaction-diffusion equations
dc.subject.lcshDictyostelium discoideum
dc.subject.lcshSelf-organizing systems
dc.subject.otherCytofission
dc.subject.otherActin waves
dc.subject.otherReaction-diffusion systems
dc.subject.otherDictyostelium discoideum
dc.subject.otherSelf-organization
dc.titleHow cortical waves drive fission of motile cells
dc.typeArticle
dc.subject.lemacEquacions de reacció-difusió
dc.subject.lemacSistemes autoorganitzatius
dc.contributor.groupUniversitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos
dc.identifier.doi10.1073/pnas.1912428117
dc.relation.publisherversionhttps://www.pnas.org/content/117/12/6330
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac28443563
dc.description.versionPostprint (published version)
dc.date.lift2020-09-25
local.citation.authorFlemming, S.; Font, F.; Alonso, S.; Beta, C.
local.citation.publicationNameProceedings of the National Academy of Sciences of the United States of America
local.citation.volume117
local.citation.number12
local.citation.startingPage6330
local.citation.endingPage6338


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain