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dc.contributor.authorTinajero, Ernesto
dc.contributor.authorMartínez de Ilarduya Sáez de Asteasu, Domingo Antxon
dc.contributor.authorMuñoz Guerra, Sebastián
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Polímers i Biopolímers
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2020-05-19T08:36:53Z
dc.date.available2020-05-19T08:36:53Z
dc.date.issued2020-04-24
dc.identifier.citationTinajero, E.; Martinez de Ilarduya, A.; Muñoz, S. Copolymacrolactones grafted with L-glutamic acid: Synthesis, structure, and nanocarrier properties. "Polymers", 24 Abril 2020, vol. 12, núm. 4, p. 995:1-995;18.
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/2117/188035
dc.description.abstractThe enzymatic ring-opening copolymerization (eROP) of globalide (Gl) and pentadecalactone (PDL) was performed in solution from mixtures of the two macrolactones at ratios covering the whole range of comonomeric compositions. The resulting P(Glx-r-PDLy) random copolyesters were aminofunctionalized by thiol-ene reaction with aminoethanethiol. ROP of ¿-benzyl-l-glutamate N-carboxyanhydride initiated by P(Glx-r-PDLy)-NH2 provided neutral poly(¿-benzyl-L-glutamate)-grafted copolyesters, which were converted by hydrolysis into negatively charged hybrid copolymers. Both water-soluble and nonsoluble copolymers were produced depending on copolymer charge and their grafting degree, and their capacity for self-assembling in nano-objects were comparatively examined. The emulsion solvent-evaporation technique applied to the chloroform-soluble copolymers grafted with benzyl glutamate rendered well-delineated spherical nanoparticles with an average diameter of 200–300 nm. Conversely, micellar solutions in water were produced from copolyesters bearing grafted chains composed of at least 10 units of glutamic acid in the free form. The copolymer micelles were shown to be able to load doxorubicin (DOX) efficiently through electrostatic interactions and also to release the drug at a rate that was markedly pH dependent.
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshPolymers
dc.subject.lcshCopolymers
dc.subject.lcshPolymerization
dc.subject.lcshPeptides
dc.subject.otherMacrolactones ROP
dc.subject.otherPentadecanolactone ROP
dc.subject.otherGlobalide ROP
dc.subject.otherMacrolactones copolyesters
dc.subject.otherPolyester-polypeptide graft copolymers
dc.subject.otherPolyglutamic grafted polyesters
dc.subject.otherMacrolactones copolyesters
dc.subject.otherUnsaturated copolymacrolactones
dc.subject.otherPolyglutamic grafted copolymacrolactones
dc.subject.otherMacrolactones nanoparticles
dc.titleCopolymacrolactones grafted with L-glutamic acid: Synthesis, structure, and nanocarrier properties
dc.typeArticle
dc.subject.lemacPolímers
dc.subject.lemacCopolímers
dc.subject.lemacPolimerització
dc.subject.lemacPèptids
dc.contributor.groupUniversitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics
dc.identifier.doi10.3390/polym12040995
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/12/4/995/htm
dc.rights.accessOpen Access
local.identifier.drac27812043
dc.description.versionPostprint (published version)
dc.relation.projectidinfo:eu-repo/grantAgreement/MINECO/1PE/MAT2016-77345-C3-1-P
dc.relation.projectidinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-095041-B-C33/ES/SISTEMAS DE LIBERACION DE FARMACOS BASADOS EN POLIMEROS AVANZADOS PARA EL TRATAMIENTO DE ENFERMEDADES GASTROINTESTINALES: POLIESTERES ANFIFILICOS Y BIOPOLIMEROS CARBOXILADOS/
local.citation.authorTinajero, E.; Martinez de Ilarduya, A.; Muñoz, S.
local.citation.publicationNamePolymers
local.citation.volume12
local.citation.number4
local.citation.startingPage995:1
local.citation.endingPage995;18


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