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dc.contributor.authorRuseva, Konstans
dc.contributor.authorIvanova, Kristina Dimitrova
dc.contributor.authorTodorova, Katerina
dc.contributor.authorVladov, Ivelin
dc.contributor.authorNanev, Vesselin
dc.contributor.authorTzanov, Tzanko
dc.contributor.authorHinojosa-Caballero, Dolores
dc.contributor.authorArgirova, Maya
dc.contributor.authorVassileva, Elena
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2020-05-11T08:51:16Z
dc.date.issued2020-04-12
dc.identifier.citationRuseva, K. [et al.]. Antibiofilm poly(carboxybetaine methacrylate) hydrogels for chronic wounds dressings. "European polymer journal", 12 Abril 2020, vol. 132, núm. 5, p. 109673:1-109673:10.
dc.identifier.issn0014-3057
dc.identifier.urihttp://hdl.handle.net/2117/186976
dc.description.abstractThe current study demonstrates the benefits of poly(carboxybetaine methacrylate) hydrogels in chronic wound healing. These hydrogels demonstrate high absorbing capacity upon swelling in salt solutions thus revealing great potential as dressings for highly exuding chronic wounds. Moreover, upon swelling they expand, increasing their volume by 25%, which makes them patient friendly ensuring also the proper wound healing. Poly(carboxybetaine methacrylate) hydrogels were also shown to absorb collagenase and myeloperoxidase, two enzymes that are specific for chronic wounds, reducing in this way their amount by 30-45 % in the wound bed without entirely inhibiting their activity, as the latter is necessary for the wound healing process. The hydrogels were also shown to be non-cytotoxic as well as to prevent the biofilm formation of S. Aureus. The in vivo implantation in rats showed no immune response to moderate immune reaction for both studied PCB hydrogels. Thus, the properties of the PCB networks revealed in the study demonstrate their potential as chronic wounds dressing materials.
dc.language.isoeng
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica
dc.subject.lcshWounds and injuries
dc.subject.lcshBiomedical materials
dc.subject.lcshPolymers in medicine
dc.subject.otherPolyzwitterions
dc.subject.otherChronic wound dressings
dc.subject.otherAntipolyelectrolyte behavior
dc.subject.otherPH and salt responsiveness
dc.subject.otherAntibiofilm activity
dc.subject.otherBiocompatibility
dc.titleAntibiofilm poly(carboxybetaine methacrylate) hydrogels for chronic wounds dressings
dc.typeArticle
dc.subject.lemacFerides i lesions
dc.subject.lemacMaterials biomèdics
dc.subject.lemacPolímers en medicina
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.1016/j.eurpolymj.2020.109673
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www-sciencedirect-com.recursos.biblioteca.upc.edu/science/article/pii/S0014305720301208
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac27761864
dc.description.versionPostprint (author's final draft)
dc.date.lift2022-06-05
local.citation.authorRuseva, K.; Ivanova, K.; Todorova, K.; Vladov, I.; Nanev, V.; Tzanov, T.; Hinojosa-Caballero, D.; Argirova, M.; Vassileva, E.
local.citation.publicationNameEuropean polymer journal
local.citation.volume132
local.citation.number5
local.citation.startingPage109673:1
local.citation.endingPage109673:10


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain