Antibiofilm poly(carboxybetaine methacrylate) hydrogels for chronic wounds dressings
dc.contributor.author | Ruseva, Konstans |
dc.contributor.author | Ivanova, Kristina Dimitrova |
dc.contributor.author | Todorova, Katerina |
dc.contributor.author | Vladov, Ivelin |
dc.contributor.author | Nanev, Vesselin |
dc.contributor.author | Tzanov, Tzanko |
dc.contributor.author | Hinojosa-Caballero, Dolores |
dc.contributor.author | Argirova, Maya |
dc.contributor.author | Vassileva, Elena |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2020-05-11T08:51:16Z |
dc.date.issued | 2020-04-12 |
dc.identifier.citation | Ruseva, K. [et al.]. Antibiofilm poly(carboxybetaine methacrylate) hydrogels for chronic wounds dressings. "European polymer journal", 12 Abril 2020, vol. 132, núm. 5, p. 109673:1-109673:10. |
dc.identifier.issn | 0014-3057 |
dc.identifier.uri | http://hdl.handle.net/2117/186976 |
dc.description.abstract | The current study demonstrates the benefits of poly(carboxybetaine methacrylate) hydrogels in chronic wound healing. These hydrogels demonstrate high absorbing capacity upon swelling in salt solutions thus revealing great potential as dressings for highly exuding chronic wounds. Moreover, upon swelling they expand, increasing their volume by 25%, which makes them patient friendly ensuring also the proper wound healing. Poly(carboxybetaine methacrylate) hydrogels were also shown to absorb collagenase and myeloperoxidase, two enzymes that are specific for chronic wounds, reducing in this way their amount by 30-45 % in the wound bed without entirely inhibiting their activity, as the latter is necessary for the wound healing process. The hydrogels were also shown to be non-cytotoxic as well as to prevent the biofilm formation of S. Aureus. The in vivo implantation in rats showed no immune response to moderate immune reaction for both studied PCB hydrogels. Thus, the properties of the PCB networks revealed in the study demonstrate their potential as chronic wounds dressing materials. |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria biomèdica |
dc.subject.lcsh | Wounds and injuries |
dc.subject.lcsh | Biomedical materials |
dc.subject.lcsh | Polymers in medicine |
dc.subject.other | Polyzwitterions |
dc.subject.other | Chronic wound dressings |
dc.subject.other | Antipolyelectrolyte behavior |
dc.subject.other | PH and salt responsiveness |
dc.subject.other | Antibiofilm activity |
dc.subject.other | Biocompatibility |
dc.title | Antibiofilm poly(carboxybetaine methacrylate) hydrogels for chronic wounds dressings |
dc.type | Article |
dc.subject.lemac | Ferides i lesions |
dc.subject.lemac | Materials biomèdics |
dc.subject.lemac | Polímers en medicina |
dc.contributor.group | Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial |
dc.identifier.doi | 10.1016/j.eurpolymj.2020.109673 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://www-sciencedirect-com.recursos.biblioteca.upc.edu/science/article/pii/S0014305720301208 |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 27761864 |
dc.description.version | Postprint (author's final draft) |
dc.date.lift | 2022-06-05 |
local.citation.author | Ruseva, K.; Ivanova, K.; Todorova, K.; Vladov, I.; Nanev, V.; Tzanov, T.; Hinojosa-Caballero, D.; Argirova, M.; Vassileva, E. |
local.citation.publicationName | European polymer journal |
local.citation.volume | 132 |
local.citation.number | 5 |
local.citation.startingPage | 109673:1 |
local.citation.endingPage | 109673:10 |
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