Articles de revista
Recent Submissions
-
Statistical modeling to adjust for time trends in adaptive platform trials utilizing non-concurrent controls
(2025-06-10)
Article
Open AccessUtilizing non-concurrent control (NCC) data in the analysis of late-entering arms in platform trials has recently received considerable attention. While incorporating NCC can lead to increased power and lower sample sizes, ... -
Treatment-control comparisons in platform trials including non-concurrent controls
(2025-06-18)
Article
Open AccessShared controls in platform trials comprise concurrent and non-concurrent controls. For a given experimental arm, non-concurrent controls refer to data from patients allocated to the control arm before the arm enters the ... -
Why and how should we simulate platform trials? Learnings from EU-PEARL
(Springer, 2025-01-17)
Article
Open AccessBackground Platform trials are innovative clinical trials governed by a master protocol that allows for the evaluation of multiple investigational treatments that enter and leave the trial over time. Interest in platform ... -
Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL
(Elsevier, 2024-01)
Article
Open AccessPlatform trials bring the promise of making clinical research more efficient and more patient centric. While their usehas become more widespread, including their prominent role during the COVID-19 pandemic response, ... -
Formalizing sustainable urban mobility management: an innovative approach with digital twin and integrated modeling
(Multidisciplinary Digital Publishing Institute (MDPI), 2024-11-11)
Article
Open AccessBackground: Urban mobility management faces growing challenges that require the analysis and optimization of sustainable solutions. Digital twins (DTs) have emerged as innovative tools for this assessment, but their ... -
Watching the guards: a data-driven method to trigger warnings in national wastewater surveillance networks
(2024-06-12)
Article
Open AccessSurveillance networks have been established in many countries worldwide to monitor SARS-CoV-2 in sewage and to estimate the communal prevalence of COVID-19 cases. Despite their popularity, gaining a rapid understanding of ... -
On model-based time trend adjustments in platform trials with non-concurrent controls
(Springer, 2022-08-15)
Article
Open AccessPlatform trials can evaluate the efficacy of several experimental treatments compared to a control. The number of experimental treatments is not fixed, as arms may be added or removed as the trial progresses. Platform ... -
NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls
(2023-07)
Article
Open AccessPlatform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in ... -
A unified formal framework for factorial and probabilistic topic modelling
(Multidisciplinary Digital Publishing Institute (MDPI), 2023-10-21)
Article
Open AccessTopic modelling has become a highly popular technique for extracting knowledge from texts. It encompasses various method families, including Factorial methods, Probabilistic methods, and Natural Language Processing methods. ... -
SurvLIMEpy: a Python package implementing SurvLIME
(2024-03-01)
Article
Restricted access - publisher's policyIn this paper we present SurvLIMEpy, an open-source Python package that implements the SurvLIME algorithm. This method allows to compute local feature importance for machine learning algorithms designed for modelling ... -
Conditional poisson regression with random effects for the analysis of multi-site time series studies
(2023-09-12)
Article
Open AccessThe analysis of time series studies linking daily counts of a health indicator with environmental variables (e.g., mortality or hospital admissions with air pollution concentrations or temperature; or motor vehicle crashes ... -
Scalability evaluation of forecasting methods applied to bicycle sharing systems
(Elsevier Ltd, 2023-10)
Article
Open AccessPublic Bicycle Sharing Systems have spread in many cities for the last decade. The need of analysis tools to predict the behavior or estimate balancing needs has fostered a wide set of approaches that consider many variables. ...