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  • Statistical modeling to adjust for time trends in adaptive platform trials utilizing non-concurrent controls 

    Krotka, Pavla; Posch, Martin; Gewily, Mohamed; Höglinger, Günter; Bofill Roig, Marta (2025-06-10)
    Article
    Open Access
    Utilizing non-concurrent control (NCC) data in the analysis of late-entering arms in platform trials has recently received considerable attention. While incorporating NCC can lead to increased power and lower sample sizes, ...

  • Treatment-control comparisons in platform trials including non-concurrent controls 

    Bofill Roig, Marta; Krotka, Pavla; Hees, Katharina; König, Franz; Magirr, Dominic; Jacko, Peter; Parke, Tom; Posch, Martin (2025-06-18)
    Article
    Open Access
    Shared controls in platform trials comprise concurrent and non-concurrent controls. For a given experimental arm, non-concurrent controls refer to data from patients allocated to the control arm before the arm enters the ...

  • Why and how should we simulate platform trials? Learnings from EU-PEARL 

    Meyer, Elias Laurin; Mielke, Tobias; Bofill Roig, Marta; Freitag, Michaela Maria; Jacko, Peter; Krotka, Pavla; Mesenbrink, Peter; Parke, Tom; Zehetmayer, Sonja; Zocholl, Dario; König, Franz (Springer, 2025-01-17)
    Article
    Open Access
    Background Platform trials are innovative clinical trials governed by a master protocol that allows for the evaluation of multiple investigational treatments that enter and leave the trial over time. Interest in platform ...

  • Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL 

    Koenig, Frank; Spiertz, Cecile; Pericàs Pulido, Juan Manuel; Sena, Elena; Krotka, Pavla; Zehetmayer, Sonja; Cirillo, Davide; Zocholl, Dario; Freitag, Michaela Maria; Gold, Stefan M.; Galea Apolo, Nemesio; Viele, Kert; Jacko, Peter; Sallaberry, Silvina; Parke, Tom; Hofner, Benjamin; Burgwinkel, Cora; Hees, Katharina; Nguyen, Quynh; Davies, Ewan; Todorovic, Marija S.; Sandor, Molnar; Morello, Salvatore; Mielke, Tobias; Magirr, Dominic; Glimm, Ekkehard; Mesenbrink, Peter; Burman, Carl-Fredrik; Gidh-Jain, Madhavi; Pierre, Suzanne; Jian, Zou; Bofill Roig, Marta (Elsevier, 2024-01)
    Article
    Open Access
    Platform trials bring the promise of making clinical research more efficient and more patient centric. While their usehas become more widespread, including their prominent role during the COVID-19 pandemic response, ...

  • Formalizing sustainable urban mobility management: an innovative approach with digital twin and integrated modeling 

    Grotto, Andrea; Fonseca Casas, Pau; Zubaryeva, Alyona; Sparber, Wolfram (Multidisciplinary Digital Publishing Institute (MDPI), 2024-11-11)
    Article
    Open Access
    Background: Urban mobility management faces growing challenges that require the analysis and optimization of sustainable solutions. Digital twins (DTs) have emerged as innovative tools for this assessment, but their ...

  • Watching the guards: a data-driven method to trigger warnings in national wastewater surveillance networks 

    Bosch-Lladó, Lluís; Pueyo-Ros, Josep; Comas Cufí, Marc; Saldaña Meca, Joan; Ripoll Missé, Jordi; Calle Ortega, Eusebio; Fonseca Casas, Pau; Garcia Subirana, Joan; Borrego-More, Carles; Corominas Tabares, Lluis (2024-06-12)
    Article
    Open Access
    Surveillance networks have been established in many countries worldwide to monitor SARS-CoV-2 in sewage and to estimate the communal prevalence of COVID-19 cases. Despite their popularity, gaining a rapid understanding of ...

  • On model-based time trend adjustments in platform trials with non-concurrent controls 

    Bofill Roig, Marta; Krotka, Pavla; Burman, Carl-Fredrik; Glimm, Ekkehard; Gold, Stefan M.; Hees, Katharina; Jacko, Peter; Koenig, Frank; Magirr, Dominic; Mesenbrink, Peter; Viele, Kert; Posch, Martin (Springer, 2022-08-15)
    Article
    Open Access
    Platform trials can evaluate the efficacy of several experimental treatments compared to a control. The number of experimental treatments is not fixed, as arms may be added or removed as the trial progresses. Platform ...

  • NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls 

    Krotka, Pavla; Hees, Katharina; Jacko, Peter; Magirr, Dominic; Posch, Martin; Bofill Roig, Marta (2023-07)
    Article
    Open Access
    Platform trials evaluate the efficacy of multiple treatments, allowing for late entry of the experimental arms and enabling efficiency gains by sharing controls. The power of individual treatment-control comparisons in ...

  • A unified formal framework for factorial and probabilistic topic modelling 

    Gibert, Karina; Hernández Potiomkin, Yaroslav (Multidisciplinary Digital Publishing Institute (MDPI), 2023-10-21)
    Article
    Open Access
    Topic modelling has become a highly popular technique for extracting knowledge from texts. It encompasses various method families, including Factorial methods, Probabilistic methods, and Natural Language Processing methods. ...

  • SurvLIMEpy: a Python package implementing SurvLIME 

    Pachón García, Cristian; Hernández Pérez, Carlos; Delicado Useros, Pedro Francisco; Vilaplana Besler, Verónica (2024-03-01)
    Article
    Restricted access - publisher's policy
    In this paper we present SurvLIMEpy, an open-source Python package that implements the SurvLIME algorithm. This method allows to compute local feature importance for machine learning algorithms designed for modelling ...

  • Conditional poisson regression with random effects for the analysis of multi-site time series studies 

    Barrera Gómez, Jose Antonio; Puig Oriol, Xavier; Ginebra Molins, Josep; Basagaña Flores, Xavier (2023-09-12)
    Article
    Open Access
    The analysis of time series studies linking daily counts of a health indicator with environmental variables (e.g., mortality or hospital admissions with air pollution concentrations or temperature; or motor vehicle crashes ...

  • Scalability evaluation of forecasting methods applied to bicycle sharing systems 

    Cortez Ordóñez, Alexandra Piedad; Vázquez Alcocer, Pere Pau; Sánchez Espigares, Josep Anton (Elsevier Ltd, 2023-10)
    Article
    Open Access
    Public Bicycle Sharing Systems have spread in many cities for the last decade. The need of analysis tools to predict the behavior or estimate balancing needs has fostered a wide set of approaches that consider many variables. ...

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