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dc.contributor.authorRey Viñoles, Sergi
dc.contributor.authorCastaño Linares, Óscar
dc.contributor.authorRuiz Macarrilla, Leonardo
dc.contributor.authorLlorens, Xavier
dc.contributor.authorMora Guix, José M.
dc.contributor.authorEngel López, Elisabeth
dc.contributor.authorMateos Timoneda, Miguel Ángel
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Ciència i Enginyeria dels Materials
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.date.accessioned2020-04-20T12:43:42Z
dc.date.available2020-04-20T12:43:42Z
dc.date.issued2019-01-01
dc.identifier.citationRey, S. [et al.]. Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches. "PloS one", 1 Gener 2019, vol. 14, núm. 11, p. e0224661:1-e0224661:15.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/2117/184021
dc.description.abstractRotator cuff tear is one of the most common shoulder diseases. Rotator cuff augmentation (RCA) is trying to solve the high retear failure percentage after the surgery procedures (20–90%). The ideal augmentation patch must provide a temporal mechanical support during the healing process. In this work, we proposed a simple method for the fabrication of synthetic RCA patches. This method combines the use of electrospraying to produce poly-L-lactic-co-e-caprolactone (PLC) films in an organogel form and electrospinning to produce poly(lactic) acid (PLA) nanofibers. The device consists in a combination of layers, creating a multilayered construct, enabling the possibility of tuning its mechanical properties and thickness. Besides, both techniques are simple to escalate for industrial production. A complete characterization has been performed to optimize the involved number of layers and production time of PLC films and PLA nanofibers fabrication, obtaining a final optimal configuration for RCA devices. Structural, mechanical and suture properties were evaluated. Also, the possibility of surface functionalization to improve the bioactivity of the scaffold was studied, adding aligned electrospun PLA nanofibers on the surface of the device to mimic the natural tendon topography. Surface modification was characterized by culturing adult normal human dermal fibroblasts. Lack of toxicity was detected for material presented, and cell alignment shape orientation guided by aligned fibers, mimicking tendon structure, was obtained. Cell proliferation and protein production were also evaluated.
dc.language.isoeng
dc.publisherPublic Library of Science (PLOS)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
dc.subject.lcshBiomedical materials
dc.titleDevelopment of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
dc.typeArticle
dc.subject.lemacMaterials biomèdics
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
dc.identifier.doi10.1371/journal.pone.0224661
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224661
dc.rights.accessOpen Access
local.identifier.drac26012004
dc.description.versionPostprint (published version)
local.citation.authorRey, S.; Castaño, Ó.; Ruiz, L.; Llorens, X.; Mora, J.; Engel, E.; Mateos, M.
local.citation.publicationNamePloS one
local.citation.volume14
local.citation.number11
local.citation.startingPagee0224661:1
local.citation.endingPagee0224661:15


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain