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dc.contributor.authorBarba Serrahima, Albert
dc.contributor.authorDíez Escudero, Anna
dc.contributor.authorEspañol Pons, Montserrat
dc.contributor.authorBonany Mariñosa, Mar
dc.contributor.authorSadowska, Joanna Maria
dc.contributor.authorGuillem Martí, Jordi
dc.contributor.authorOhman, Caroline
dc.contributor.authorPersson, Cecilia
dc.contributor.authorManzanares, Maria Cristina
dc.contributor.authorFranch, Jordi
dc.contributor.authorGinebra Molins, Maria Pau
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Enginyeria Biomèdica
dc.date.accessioned2020-04-20T08:38:27Z
dc.date.available2020-04-20T08:38:27Z
dc.date.issued2019-01-01
dc.identifier.citationBarba, A. [et al.]. Impact of biomimicry in the design of osteoinductive bone substitutes: nanoscale matters. "ACS Applied materials and interfaces", 1 Gener 2019, vol. 11, núm. 9, p. 8818-8830.
dc.identifier.issn1944-8252
dc.identifier.urihttp://hdl.handle.net/2117/183955
dc.description.abstractBone apatite consists of carbonated calcium-deficient hydroxyapatite (CDHA) nanocrystals. Biomimetic routes allow fabricating synthetic bone grafts that mimic biological apatite. In this work, we explored the role of two distinctive features of biomimetic apatites, namely, nanocrystal morphology (plate vs needle-like crystals) and carbonate content, on the bone regeneration potential of CDHA scaffolds in an in vivo canine model. Both ectopic bone formation and scaffold degradation were drastically affected by the nanocrystal morphology after intramuscular implantation. Fine-CDHA foams with needle-like nanocrystals, comparable in size to bone mineral, showed a markedly higher osteoinductive potential and a superior degradation than chemically identical coarse-CDHA foams with larger plate-shaped crystals. These findings correlated well with the superior bone-healing capacity showed by the fine-CDHA scaffolds when implanted intraosseously. Moreover, carbonate doping of CDHA, which resulted in small plate-shaped nanocrystals, accelerated both the intrinsic osteoinduction and the bone healing capacity, and significantly increased the cell-mediated resorption. These results suggest that tuning the chemical composition and the nanostructural features may allow the material to enter the physiological bone remodeling cycle, promoting a tight synchronization between scaffold degradation and bone formation.
dc.format.extent13 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials
dc.subject.lcshBiomimetics
dc.subject.lcshCalcium phosphate
dc.subject.otherBiomimetic
dc.subject.otherCalcium phosphate
dc.subject.otherCarbonated apatite
dc.subject.otherNanostructure
dc.subject.otherFoaming
dc.subject.otherOsteoinduction
dc.subject.otherOsteogenesis
dc.titleImpact of biomimicry in the design of osteoinductive bone substitutes: nanoscale matters
dc.typeArticle
dc.subject.lemacBiomimètica
dc.subject.lemacFosfat de calci
dc.subject.lemacOssos
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1021/acsami.8b20749
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acsami.8b20749
dc.rights.accessOpen Access
local.identifier.drac23997344
dc.description.versionPostprint (author's final draft)
dc.contributor.covenanteeUniversitat Autònoma de Barcelona
dc.contributor.covenanteeUppsala universitet
dc.contributor.covenanteeUniversitat de Barcelona. Departament de Patologia i Terapèutica Experimental
dc.contributor.covenanteeInstitut de Bioenginyeria de Catalunya
local.citation.authorBarba, A.; Diez-Escudero, A.; Español, M.; Bonany, M.; Sadowska, J.; Guillem-Marti, J.; Ohman, C.; Persson, C.; Manzanares, M.; Franch, J.; Ginebra, M.P.
local.citation.publicationNameACS Applied materials and interfaces
local.citation.volume11
local.citation.number9
local.citation.startingPage8818
local.citation.endingPage8830


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain