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Impact of biomimicry in the design of osteoinductive bone substitutes: nanoscale matters

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Barba Serrahima, Albert
Díez Escudero, AnnaMés informacióMés informació
Español Pons, MontserratMés informacióMés informacióMés informació
Bonany Mariñosa, MarMés informacióMés informació
Sadowska, Joanna MariaMés informació
Guillem Martí, JordiMés informacióMés informacióMés informació
Ohman, Caroline
Persson, Cecilia
Manzanares, Maria Cristina
Franch, Jordi
Ginebra Molins, Maria PauMés informacióMés informacióMés informació
CovenanteeUniversitat Autònoma de Barcelona; Uppsala universitet; Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental; Institut de Bioenginyeria de Catalunya
Document typeArticle
Defense date2019-01-01
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Bone apatite consists of carbonated calcium-deficient hydroxyapatite (CDHA) nanocrystals. Biomimetic routes allow fabricating synthetic bone grafts that mimic biological apatite. In this work, we explored the role of two distinctive features of biomimetic apatites, namely, nanocrystal morphology (plate vs needle-like crystals) and carbonate content, on the bone regeneration potential of CDHA scaffolds in an in vivo canine model. Both ectopic bone formation and scaffold degradation were drastically affected by the nanocrystal morphology after intramuscular implantation. Fine-CDHA foams with needle-like nanocrystals, comparable in size to bone mineral, showed a markedly higher osteoinductive potential and a superior degradation than chemically identical coarse-CDHA foams with larger plate-shaped crystals. These findings correlated well with the superior bone-healing capacity showed by the fine-CDHA scaffolds when implanted intraosseously. Moreover, carbonate doping of CDHA, which resulted in small plate-shaped nanocrystals, accelerated both the intrinsic osteoinduction and the bone healing capacity, and significantly increased the cell-mediated resorption. These results suggest that tuning the chemical composition and the nanostructural features may allow the material to enter the physiological bone remodeling cycle, promoting a tight synchronization between scaffold degradation and bone formation.
CitationBarba, A. [et al.]. Impact of biomimicry in the design of osteoinductive bone substitutes: nanoscale matters. "ACS Applied materials and interfaces", 1 Gener 2019, vol. 11, núm. 9, p. 8818-8830. 
URIhttp://hdl.handle.net/2117/183955
DOI10.1021/acsami.8b20749
ISSN1944-8252
Publisher versionhttps://pubs.acs.org/doi/10.1021/acsami.8b20749
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  • Doctorat en Enginyeria Biomèdica - Articles de revista [95]
  • Departament de Ciència i Enginyeria de Materials - Articles de revista [656]
  • BBT - Grup de recerca en Biomaterials, Biomecànica i Enginyeria de Teixits - Articles de revista [407]
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