Collagen orientation and waviness within the vein wall
Document typeConference report
Rights accessOpen Access
This paper presents the analysis of the internal structure and organization of components within the vein wall. Dominant directions and statistical distribution of collagen fibers undulation were investigated in digitalized histological sections from media and adventitia layer of human vena cava inferior. Orientations of collagen fibers were analyzed by the in-house developed software Binary Directions. Digital images were converted to binary pixel maps with collagen fibers enhanced. The software employs an algorithm of the Rotation Line Segment to determine significant directions in digital images. It was found that collagen fibers are aligned in circumferential direction in media layer. Contrary to that in adventitia fibers are arranged in longitudinal direction. In contrast to elastic artery, no evidence of helically reinforced composite structure was found. Second goal was to find out which statistical distribution, usually using in structural models (Gamma, Beta or Weibull), fits to the undulation distribution of collagen fibers. Collagen waviness was characterized by a probability density function for the strain necessary to straighten a crimped fiber. Computer analysis of the end-to-end and contour length was performed using Nis-Elements software. The statistical analysis suggests that the waviness of collagen fibers is identical in media and adventitia It was found that the average strain necessary for straightening collagen fibers is 0.24±0.11 (±SD) and that all three probability distributions fit straightening strains very well and can be used in structural models
CitationVesely, J. [et al.]. Collagen orientation and waviness within the vein wall. A: COMPLAS XI. "COMPLAS XI : proceedings of the XI International Conference on Computational Plasticity : fundamentals and applications". CIMNE, 2011, p. 720-728.
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