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dc.contributor.authorRivas Cañas, Manuel
dc.contributor.authorPelechà Casanovas, Marc
dc.contributor.authorFranco García, María Lourdes
dc.contributor.authorTuron, Pau
dc.contributor.authorAlemán Llansó, Carlos
dc.contributor.authorValle Mendoza, Luis Javier del
dc.contributor.authorPuiggalí Bellalta, Jordi
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Polímers i Biopolímers
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2020-04-17T11:58:37Z
dc.date.available2020-04-17T11:58:37Z
dc.date.issued2019-10-02
dc.identifier.citationRivas, M. [et al.]. Incorporation of chloramphenicol loaded hydroxyapatite nanoparticles into polylactide. "International journal of molecular sciences", 2 Octubre 2019, vol. 20, núm. 20, p. 5056:1-5056:17.
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/2117/183796
dc.description.abstractChloramphenicol (CAM) has been encapsulated into hydroxyapatite nanoparticles displaying different morphologies and crystallinities. The process was based on typical precipitation of solutions containing phosphate and calcium ions and the addition of CAM once the hydroxyapatite nuclei were formed. This procedure favored a disposition of the drug into the bulk parts of the nanoparticles and led to a fast release in aqueous media. Clear antibacterial activity was derived, being slightly higher for the amorphous samples due to their higher encapsulation efficiency. Polylactide (PLA) microfibers incorporating CAM encapsulated in hydroxyapatite nanoparticles were prepared by the electrospinning technique and under optimized conditions. Drug release experiments demonstrated that only a small percentage of the loaded CAM could be delivered to an aqueous PBS medium. This amount was enough to render an immediate bacteriostatic effect without causing a cytotoxic effect on osteoblast-like, fibroblasts, and epithelial cells. Therefore, the prepared scaffolds were able to retain CAM-loaded nanoparticles, being a reservoir that should allow a prolonged release depending on the polymer degradation rate. The studied system may have promising applications for the treatment of cancer since CAM has been proposed as a new antitumor drug.
dc.language.isoeng
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshDrugs
dc.subject.otherHydroxyapatite
dc.subject.otherChloramphenicol
dc.subject.otherPolylactide
dc.subject.otherElectrospun scaffolds
dc.subject.otherDrug encapsulation
dc.subject.otherDrug release
dc.titleIncorporation of chloramphenicol loaded hydroxyapatite nanoparticles into polylactide
dc.typeArticle
dc.subject.lemacMedicaments
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
dc.identifier.doi10.3390/ijms20205056
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/20/20/5056
dc.rights.accessOpen Access
local.identifier.drac26426664
dc.description.versionPostprint (published version)
local.citation.authorRivas, M.; Pelechà, M.; Franco, L.; Turon, P.; Aleman, C.; del Valle, LJ.; Puiggali, J.
local.citation.publicationNameInternational journal of molecular sciences
local.citation.volume20
local.citation.number20
local.citation.startingPage5056:1
local.citation.endingPage5056:17


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