T-wave morphology changes as surrogate for blood potassium concentration in hemodialysis patients
Document typeConference report
Rights accessOpen Access
End-stage renal disease (ESRD) patients undergoing hemodialysis (HD) are at high risk of arrhythmias and sudden cardiac death as a result of blood potassium con-centration ([K+]) changes.The aim of this study is to investigate if dw, a time-warping-based electrocardiogram (ECG) biomarker of T-wave morphology changes,reflects [K+] evolution in HD patients, facilitating non-invasive [K+] monitoring and avoiding in-hospital blood tests analysis. 48-hour ECGs and a set of hourly collected blood samples from 12 ESRD patients were acquired and analyzed. dw was calculated between a reference T-wave,measured at the end of the HD session, and the T-waves corresponding to each hour along the whole HD session,when [K+] was measured from blood samples. The values of dw correlated with the relative variations in [K+] with respect to the reference value (end of HD,¿[K+]), with a median (interquartile) correlation coefficient of 0.90(0.30), evidencing a strong relation between them. Our findings support the use of dw as a surrogate of¿[K+],suggesting a potential use of dw for non-invasive hyperkalemia monitoring both in hospital and ambulatory settings.
CitationPalmieri, F. [et al.]. T-wave morphology changes as surrogate for blood potassium concentration in hemodialysis patients. A: Computers in Cardiology. "Computing in cardiology 2019". 2019, p. 109:1-109:4.