The Membrane proximal domain of TRPV1 and TRPV2 channels mediates protein-protein interactions and lipid binding in vitro

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Document typeArticle
Defense date2019-02-05
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ProjectPAIN_TRPV2 - Single Particle Cryo-Electron Microscopy and Biophysical Characterization of Transient Receptor Potential Vanilloid 2 channel: a Three-Dimensional Structure Characterization of a Membrane Nociceptor. (EC-FP7-237120)
SOCRATES - European Training Network for the sustainable, zero-waste valorisation of (critical) metal containing industrial process residues (EC-H2020-721385)
PAIN_TRPV2 - Single Particle Cryo-Electron Microscopy and Biophysical Characterization of Transient Receptor Potential Vanilloid 2 channel: a Three-Dimensional Structure Characterization of a Membrane Nociceptor. (EC-FP7-237120)
RELACION ESTRUCTURA-FUNCION DEL CANAL IONICO TRPV2 Y SUS IMPLICACIONES EN TERMOCEPCION. (MICINN-SAF2010-21385)
PROTECT - Pharmacoepidemiolocal Research on Outcomes of Therapeutics by a European ConsorTium (EC-FP7-115004)
SOCRATES - European Training Network for the sustainable, zero-waste valorisation of (critical) metal containing industrial process residues (EC-H2020-721385)
PAIN_TRPV2 - Single Particle Cryo-Electron Microscopy and Biophysical Characterization of Transient Receptor Potential Vanilloid 2 channel: a Three-Dimensional Structure Characterization of a Membrane Nociceptor. (EC-FP7-237120)
RELACION ESTRUCTURA-FUNCION DEL CANAL IONICO TRPV2 Y SUS IMPLICACIONES EN TERMOCEPCION. (MICINN-SAF2010-21385)
PROTECT - Pharmacoepidemiolocal Research on Outcomes of Therapeutics by a European ConsorTium (EC-FP7-115004)
Abstract
Constitutive or regulated membrane protein trafficking is a key cell biology process.Transient receptor potential channels are somatosensory proteins in charge of detecting severalphysical and chemical stimuli, thus requiring fine vesicular trafficking. The membrane proximalor pre-S1 domain (MPD) is a highly conserved domain in transient receptor potential channels from the vanilloid (TRPV) subfamily.
CitationDoñate, P. [et al.]. The Membrane proximal domain of TRPV1 and TRPV2 channels mediates protein-protein interactions and lipid binding in vitro. "International journal of molecular sciences", 5 Febrer 2019, vol. 20, p. 1-11.
ISSN1422-0067
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