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Red queen dynamics, competition and critical points in a model of RNA virus quasispecies
dc.contributor.author | Vicente Solé, Ricardo |
dc.contributor.author | Ferrer Cancho, Ramon |
dc.contributor.author | González García, Isabel |
dc.contributor.author | Quer, Josep |
dc.contributor.author | Domingo Solans, Esteban |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Ciències de la Computació |
dc.date.accessioned | 2020-03-18T17:26:40Z |
dc.date.issued | 1999-05-07 |
dc.identifier.citation | Vicente, R. [et al.]. Red queen dynamics, competition and critical points in a model of RNA virus quasispecies. "Journal of theoretical biology", 7 Maig 1999, vol. 198, núm. 1, p. 47-59. |
dc.identifier.issn | 0022-5193 |
dc.identifier.uri | http://hdl.handle.net/2117/180450 |
dc.description.abstract | RNA viruses offer a unique opportunity for the study of evolution at the molecular level. Recent experiments involving clonal populations of RNA viruses have shown that competition among virus strains of approximately equal relative fitness can result in the eventual competitive exclusion of one of the species. As competition proceeds in time, both the winners and the losers exhibited absolute gains in fitness, consistent with the “Red Queen” hypothesis of evolution. Further experiments involving closely related evolving quasispecies revealed a highly predictable nonlinear behavior suggesting a deterministic component in the underlying quasispecies dynamics. This is apparently in contradiction with the standard view of RNA virus evolution as a highly unpredictable process. In this paper we present a simple model which allows previous hypothesis to be tested and provides an interpretation for the observed experimental results. |
dc.format.extent | 13 p. |
dc.language.iso | eng |
dc.subject | Àrees temàtiques de la UPC::Informàtica::Aplicacions de la informàtica::Bioinformàtica |
dc.subject.lcsh | RNA viruses |
dc.subject.other | Lethal mutagenesis |
dc.subject.other | Red queen hypothesis |
dc.title | Red queen dynamics, competition and critical points in a model of RNA virus quasispecies |
dc.type | Article |
dc.subject.lemac | Virus RNA |
dc.contributor.group | Universitat Politècnica de Catalunya. GPLN - Grup de Processament del Llenguatge Natural |
dc.identifier.doi | 10.1006/jtbi.1999.0901 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0022519399909013?via%3Dihub |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 1640479 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Vicente, R.; Ferrer-i-Cancho, R.; González-García, I.; Quer, J.; Domingo, E. |
local.citation.publicationName | Journal of theoretical biology |
local.citation.volume | 198 |
local.citation.number | 1 |
local.citation.startingPage | 47 |
local.citation.endingPage | 59 |
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