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dc.contributor.authorSoldevila Domènech, Natàlia
dc.contributor.authorBoronat Rigol, Anna
dc.contributor.authorLangohr, Klaus
dc.contributor.authorDe la Torre Fornell, Rafael
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.identifier.citationSoldevila, N. [et al.]. N-of-1 clinical trials in nutritional interventions directed at improving cognitive function. "Frontiers in Nutrition", 23 Juliol 2019, vol. 6, p. 1-20.
dc.description.abstractLonger life expectancy has led to an increase in the prevalence of age-related cognitive decline and dementia worldwide. Due to the current lack of effective treatment for these conditions, preventive strategies represent a research priority. A large body of evidence suggests that nutrition is involved in the pathogenesis of age-related cognitive decline, but also that it may play a critical role in slowing down its progression. At a population level, healthy dietary patterns interventions, such as the Mediterranean and the MIND diets, have been associated with improved cognitive performance and a decreased risk of neurodegenerative disease development. In the era of evidence-based medicine and patient-centered healthcare, personalized nutritional recommendations would offer a considerable opportunity in preventing cognitive decline progression. N-of-1 clinical trials have emerged as a fundamental design in evidence-based medicine. They consider each individual as the only unit of observation and intervention. The aggregation of series of N-of-1 clinical trials also enables population-level conclusions. This review provides a general view of the current scientific evidence regarding nutrition and cognitive decline, and critically states its limitations when translating results into the clinical practice. Furthermore, we suggest methodological strategies to develop N-of-1 clinical trials focused on nutrition and cognition in an older population. Finally, we evaluate the potential challenges that researchers may face when performing studies in precision nutrition and cognition.
dc.format.extent20 p.
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Probabilitat
dc.subject.lcshSampling (Statistics)
dc.subject.otherpersonalized nutrition
dc.subject.otherAlzheimer’s disease
dc.subject.othermultimodal interventions
dc.subject.othercognitive decline
dc.titleN-of-1 clinical trials in nutritional interventions directed at improving cognitive function
dc.subject.lemacMostreig (Estadística)
dc.contributor.groupUniversitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::92 Biology and other natural sciences::92B Mathematical biology in general
dc.subject.amsClassificació AMS::92 Biology and other natural sciences::92D Genetics and population dynamics
dc.subject.amsClassificació AMS::62 Statistics::62D05 Sampling theory, sample surveys
dc.rights.accessOpen Access
dc.description.versionPostprint (published version)
local.citation.authorSoldevila, N.; Boronat, A.; Langohr, K.; De la Torre, R.
local.citation.publicationNameFrontiers in Nutrition

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