Chondrogenic differentiation of human mesenchymal stem cells in RADA16-I and methylcellulose-based bioink
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Chondrogenic Differentiation of human mesenchymal stem cells in RAD16-methyl celullose hydrogel.pdf (2,306Mb) (Accés restringit)
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Inclou dades d'ús des de 2022
Cita com:
hdl:2117/177658
Correu electrònic de l'autorugaojo-4student.ltu.se
Realitzat a/ambUniversité de Lorraine
Tipus de documentProjecte Final de Màster Oficial
Data2019-02-13
Condicions d'accésAccés restringit per decisió de l'autor
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Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Printing and investigating cell-laden and self assembeled peptide scafolds. Cartilage damage is one of the most common causes for pain and immobility worldwide. Aging populations with heavier bodies and less exercise add up to create a surge in the number of patients suffering from cartilage related damage as can be seen in the USA where 30 million patients in 2008 is expected to have risen to 60 million in 2020. Cartilage is an avascular structure with low intrinsic regeneration and the current medical remedies fail to aid the ever-growing numbers asking for it. Steps forward within the interdisciplinary field of tissue engineering seeks to combine the current available technologies to remedy these damages through personally tailoring specific patient’s cartilage and growing it in labs. This study aims to achieve chondrogenesis through combining a novel developed bioink made out of methyl cellulose and RAD16-I, a peptide that can possess the ability to self-assemble into a three-dimensional network,with 3D bioprintingand mesenchymal stem cells. The project sought one hand to better understand the bioink through performing viability studies spanning over 21 days. On the other hand, the project focusedon achieving chondrogenesis in cell laden 3D printed RAD16-I and Methylcellulose bioink. Studies demonstrated viability at all examinations, however, there were difficulties connected to the 3D bioprintingcausing cells to dieand no conclusive evidence of chondrogenesis could be presented.Newstrategies and prospects are, however, provided.
TitulacióMOBILITAT INCOMING
Fitxers | Descripció | Mida | Format | Visualitza |
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Chondrogenic Di ... hyl celullose hydrogel.pdf | 2,306Mb | Accés restringit |