Improvement of biodegradability and biocompatibility of electrospun scaffolds of poly(butylene terephthalate) by incorporation of sebacate units
Visualitza/Obre
Cita com:
hdl:2117/177449
Tipus de documentArticle
Data publicació2020-01-01
Condicions d'accésAccés obert
Llevat que s'hi indiqui el contrari, els
continguts d'aquesta obra estan subjectes a la llicència de Creative Commons
:
Reconeixement-NoComercial-SenseObraDerivada 3.0 Espanya
Abstract
Incorporation of aliphatic units to poly(butylene terephthalate) (PBT) gives rise to biodegradable copolymers with tunable properties (e.g., degradability), depending on the selected comonomer and the specific composition. Specifically, a low molecular weight poly(butylene sebacate-co-terephthalate) (PBSeT) with a high ratio of aliphatic sebacate units (i.e., 70 mol-% with respect to the total dicarboxylate content) has been employed in this work to get new electrospun biodegradable scaffolds. Appropriate electrospinning conditions have been found despite the limited copolymer molecular weight. In addition, PBSeT has been employed to improve biocompatibility and biodegradability of scaffolds based on the PBT homopolymer. Scaffolds with different properties have been prepared following two strategies: Electrospinning of single solutions of PBT and PBSeT mixtures and co-electrospinning of independent PBT and PBSeT solutions. Characterization involved spectroscopic (FTIR, NMR), calorimetric (DSC, TGA) and surface hydrophobicity analyses. Hydrolytic and enzymatic degradation studies demonstrated the success of the approach due to the susceptibility of the PBSeT component towards the enzymatic attack with lipases from Pseudomonas cepacia and even towards high temperature hydrolysis.
CitacióHeidarzadeh, N. [et al.]. Improvement of biodegradability and biocompatibility of electrospun scaffolds of poly(butylene terephthalate) by incorporation of sebacate units. "Macromolecular research", 1 Gener 2020, vol. 28, núm. 1, p. 23-32.
ISSN1598-5032
Versió de l'editorhttps://link.springer.com/article/10.1007%2Fs13233-020-8009-0
Fitxers | Descripció | Mida | Format | Visualitza |
---|---|---|---|---|
Electrospinning_Nina 2019.pdf | 2,070Mb | Visualitza/Obre |