Ir al contenido (pulsa Retorno)

Universitat Politècnica de Catalunya

    • Català
    • Castellano
    • English
    • LoginRegisterLog in (no UPC users)
  • mailContact Us
  • world English 
    • Català
    • Castellano
    • English
  • userLogin   
      LoginRegisterLog in (no UPC users)

UPCommons. Global access to UPC knowledge

Banner header
69.069 UPC E-Prints
You are here:
View Item 
  •   DSpace Home
  • E-prints
  • Grups de recerca
  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
  • Articles de revista
  • View Item
  •   DSpace Home
  • E-prints
  • Grups de recerca
  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
  • Articles de revista
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Development of a self-assembled peptide/methylcellulose-based bioink for 3D bioprinting

Thumbnail
View/Open
mame201900353.pdf (1,943Mb)
 
10.1002/mame.201900353
 
  View UPCommons Usage Statistics
  LA Referencia / Recolecta stats
Includes usage data since 2022
Cita com:
hdl:2117/177436

Show full item record
Cofiño, Carla
Pérez Amodio, Soledad GracielaMés informacióMés informació
Semino, Carlos
Engel López, ElisabethMés informacióMés informacióMés informació
Mateos Timoneda, Miguel ÁngelMés informació
Document typeArticle
Defense date2019-11-13
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
The introduction of 3D bioprinting to fabricate living constructs with tailored architecture has provided a new paradigm for biofabrication, with the potential to overcome several drawbacks of conventional scaffold-based tissue regeneration strategies. Hydrogel-based materials are suitable candidates regarding cell biocompatibility but often display poor mechanical properties. Self-assembling peptides are a promising source of biomaterials to be used as 3D scaffolds based on their similarity to extracellular matrices (structurally and mechanically). In this study, an advanced bioink for biofabrication is presented based on the optimization of a RAD16-I-based biomaterial. The strategy followed to build 3D predefined structures by 3D printing is based on an enhancement of bioink viscosity by adding methylcellulose (MC) to a RAD16-I solution. The resultant constructs display high shape fidelity and stability and embedded human mesenchymal stem cells present high viability after 7 days of culture. Moreover, cells are also able to differentiate to the adipogenic lineage, suggesting the suitability of this novel biomaterial for soft tissue engineering applications.
CitationCofiño, C. [et al.]. Development of a self-assembled peptide/methylcellulose-based bioink for 3D bioprinting. "Macromolecular materials and engineering", 13 Novembre 2019, vol. 304, núm. 11, p. 1900353:1-1900353:9. 
URIhttp://hdl.handle.net/2117/177436
DOI10.1002/mame.201900353
ISSN1438-7492
Publisher versionhttps://onlinelibrary.wiley.com/doi/abs/10.1002/mame.201900353
Collections
  • IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies - Articles de revista [445]
  • Departament de Ciència i Enginyeria de Materials - Articles de revista [913]
  View UPCommons Usage Statistics

Show full item record

FilesDescriptionSizeFormatView
mame201900353.pdf1,943MbPDFView/Open

Browse

This CollectionBy Issue DateAuthorsOther contributionsTitlesSubjectsThis repositoryCommunities & CollectionsBy Issue DateAuthorsOther contributionsTitlesSubjects

© UPC Obrir en finestra nova . Servei de Biblioteques, Publicacions i Arxius

info.biblioteques@upc.edu

  • About This Repository
  • Metadata under:Metadata under CC0
  • Contact Us
  • Send Feedback
  • Privacy Settings
  • Inici de la pàgina