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dc.contributor.authorRodríguez Contreras, Alejandra María
dc.contributor.authorGuillem Martí, Jordi
dc.contributor.authorManero Planella, José María
dc.contributor.authorRupérez de Gracia, Elisa
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials
dc.date.accessioned2020-02-10T08:06:25Z
dc.date.issued2019-10-01
dc.identifier.citationRodriguez, A. [et al.]. Antimicrobial PHAs coatings for solid and porous tantalum implants. "Colloids and Surfaces B: Biointerfaces", 1 Octubre 2019, vol. 182, p. 110317:1-110317: 9.
dc.identifier.issn1873-4367
dc.identifier.urihttp://hdl.handle.net/2117/177254
dc.description.abstractBiomaterial-associated infections (BAI) are the major cause of failure of indwelling medical devices. The risk of BAI can end dramatically in the surgical removal of the affected device. Therefore, a major effort must be undertaken to guarantee the permanence of the implant. In this regard, we have developed antimicrobial coatings for tantalum (Ta) implants, using polyhydroxyalkanoates (PHAs) as matrices for carrying an active principle. The dip-coating technique was successfully used for covering solid Ta discs. An original PHA emulsion flow process was developed for the coating of porous Ta structures, specially for the inner surfaces. The complete characterization of the biopolymer coatings, their antibacterial properties, toxicity and biointegration were analyzed. Thus, non-toxic, well-biointegrated homogeneous biopolymer coatings were attained, which showed antibacterial properties. By using biodegradable PHAs, the resulting drug delivery system assured the protection of Ta against bacterial infections for a period of time.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshTantalum
dc.subject.lcshImplants, Artificial
dc.subject.lcshBiopolymers
dc.subject.lcshTantalum
dc.subject.otherPorous tantalum
dc.subject.otherBiodegradable biopolymers
dc.subject.otherGentamicin Dip-coating technique
dc.subject.otherPolyhydroxyalkanoates
dc.subject.otherTrabecular metal.
dc.titleAntimicrobial PHAs coatings for solid and porous tantalum implants
dc.typeArticle
dc.subject.lemacPolímers -- Biodegradació
dc.subject.lemacTàntal (Química inorgànica)
dc.subject.lemacImplants artificials -- Materials
dc.subject.lemacBiopolímers
dc.contributor.groupUniversitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits
dc.identifier.doi10.1016/j.colsurfb.2019.06.047
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0927776519304539
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac25796118
dc.description.versionPostprint (author's final draft)
dc.date.lift2021-10-01
local.citation.authorRodriguez, A.; Guillem-Marti, J.; Manero, J.; Rupérez de Gracia, E.
local.citation.publicationNameColloids and Surfaces B: Biointerfaces
local.citation.volume182
local.citation.startingPage110317:1
local.citation.endingPage110317: 9


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Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain