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Associations between fine and coarse particles and mortality in Mediterranean cities: results from the MED-PARTICLES project

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Samoli, Evangelia
Stafoggia, Massimo
Rodopoulou, Sophia
Ostro, Bart
Declercq, Christophe
Alessandrini, Ester
Díaz, Julio
Karanasiou, Angeliki
Kelessis, Apostolos G.
Le Tertre, Alain
Pandolfi, Paolo
Randi, Giorgia
Scarinzi, Cecilia
Zauli-Sajani, Stefano
Katsouyanni, Klea
Forastiere, Francesco
Study Group, MED-PARTICLES
Agis Cherta, DavidMés informacióMés informació
Document typeArticle
Defense date2013-08-01
PublisherNational Institute of Environmental Health Sciences
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
This work is protected by the corresponding intellectual and industrial property rights. Except where otherwise noted, its contents are licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
Few studies have investigated the independent health effects of different size fractions of particulate matter (PM) in multiple locations, especially in Europe. We estimated the short-term effects of PM with aerodynamic diameter = 10 µm (PM10), = 2.5 µm (PM2.5), and between 2.5 and 10 µm (PM2.5–10) on all-cause, cardiovascular, and respiratory mortality in 10 European Mediterranean metropolitan areas within the MEDPARTICLES project. We analyzed data from each city using Poisson regression models, and combined cityspecific estimates to derive overall effect estimates. We evaluated the sensitivity of our estimates to co-pollutant exposures and city-specific model choice, and investigated effect modification by age, sex, and season. We applied distributed lag and threshold models to investigate temporal patterns of associations. A 10-µg/m3 increase in PM2.5 was associated with a 0.55% (95% CI: 0.27, 0.84%) increase in all-cause mortality (0–1 day cumulative lag), and a 1.91% increase (95% CI: 0.71, 3.12%) in respiratory mortality (0–5 day lag). In general, associations were stronger for cardiovascular and respiratory mortality than all-cause mortality, during warm versus cold months, and among those = 75 versus < 75 years of age. Associations with PM2.5–10 were positive but not statistically significant in most analyses, whereas associations with PM10 seemed to be driven by PM2.5. We found evidence of adverse effects of PM2.5 on mortality outcomes in the European Mediterranean region. Associations with PM2.5–10 were positive but smaller in magnitude. Associations were stronger for respiratory mortality when cumulative exposures were lagged over 0–5 days, and were modified by season and age.
CitationSamoli, E. [et al.]. Associations between fine and coarse particles and mortality in Mediterranean cities: results from the MED-PARTICLES project. "Environmental health perspectives", 1 Agost 2013, vol. 121, núm. 8, p. 932-938. 
URIhttp://hdl.handle.net/2117/175969
DOI10.1289/ehp.1206124
ISSN0091-6765
Publisher versionhttps://ehp.niehs.nih.gov/doi/10.1289/ehp.1206124
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