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Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: morphology, molecular relaxations, and controlled drug release
dc.contributor.author | Valenti, Sofia |
dc.contributor.author | Díaz Andrade, Angélica María |
dc.contributor.author | Romanini, Michela |
dc.contributor.author | Valle Mendoza, Luis Javier del |
dc.contributor.author | Puiggalí Bellalta, Jordi |
dc.contributor.author | Tamarit Mur, José Luis |
dc.contributor.author | Macovez, Roberto |
dc.contributor.other | Universitat Politècnica de Catalunya. Doctorat en Polímers i Biopolímers |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física |
dc.date.accessioned | 2020-01-22T19:12:49Z |
dc.date.available | 2020-09-10T00:29:21Z |
dc.date.issued | 2019-09-10 |
dc.identifier.citation | Valenti, S. [et al.]. Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: morphology, molecular relaxations, and controlled drug release. "International journal of pharmaceutics", 10 Setembre 2019, vol. 568, p. 1-11. |
dc.identifier.issn | 0378-5173 |
dc.identifier.uri | http://hdl.handle.net/2117/175471 |
dc.description.abstract | We study amorphous solid dispersions (ASDs) of the chloramphenicol antibiotic in two biodegradable polylactic acid polymers, namely a commercial sample of enantiomeric pure PLLA and a home-synthesized PDLLA copolymer, to study the effect of polylactic acid in stabilizing the amorphous form of the drug and controlling its release (e.g. for antitumoral purposes). We employ broadband dielectric spectroscopy and differential scanning calorimetry to study the homogeneity, glass transition temperature and relaxation dynamics of solvent-casted ASD membranes with different drug concentrations. We observe improved physical stability of the ASDs with respect to the pure drug, as well as a plasticizing effect of the antibiotic on the polymer, well described by the Gordon-Taylor equation. We study the release of the active pharmaceutical ingredient from the films in a simulated body fluid through UV/vis spectroscopy at two different drug concentrations (5 and 20% in weight), and find that the amount of released drug is proportional to the square root of time, with proportionality constant that is almost the same in both dispersions, despite the fact that the relaxation time and thus the viscosity of the two samples at body temperature differ by four orders of magnitude. The drug release kinetics does not display a significant dependence on the drug content in the carrier, and may thus be expected to remain roughly constant during longer release times. |
dc.format.extent | 11 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Física |
dc.subject.lcsh | Polylactic acid |
dc.subject.lcsh | Polymers -- Analysis |
dc.subject.other | Amorphous drug |
dc.subject.other | Polymer enantiomerism |
dc.subject.other | Pmolecular mobility |
dc.subject.other | Plasticizer dielectric spectroscopy |
dc.subject.other | Controlled liberation |
dc.title | Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: morphology, molecular relaxations, and controlled drug release |
dc.type | Article |
dc.subject.lemac | Polimers -- Anàlisi |
dc.subject.lemac | Àcid polilàctic |
dc.contributor.group | Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables |
dc.contributor.group | Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials |
dc.identifier.doi | 10.1016/j.ijpharm.2019.118565 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S037851731930609X |
dc.rights.access | Open Access |
local.identifier.drac | 25830884 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Valenti, S.; Diaz, A.; Romanini, M.; del Valle, LJ.; Puiggali, J.; Tamarit, J. Ll.; Macovez, R. |
local.citation.publicationName | International journal of pharmaceutics |
local.citation.volume | 568 |
local.citation.startingPage | 1 |
local.citation.endingPage | 11 |
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