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Atomic force microscopy-based mechanobiology

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hdl:2117/173416

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Krieg, Michael
Fläschner, Gotthold
Alsteens, David
Gaub, Benjamin M.
Roos, Wouter H.
Wuite, Gijs J. L.
Gaub, Hermann E.
Gerber, Christoph
Dufrêne, Yves F
Mülle, Daniel J.
Document typeArticle
Defense date2018-11-01
PublisherNature
Rights accessOpen Access
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
ProjectMechanoSystems - How to build a brain? Engineering molecular systems for mechanosensation and -protection in neurons (EC-H2020-715243)
Abstract
Mechanobiology emerges at the crossroads of medicine, biology, biophysics and engineering and describes how the responses of proteins, cells, tissues and organs to mechanical cues contribute to development, differentiation, physiology and disease. The grand challenge in mechanobiology is to quantify how biological systems sense, transduce, respond and apply mechanical signals. Over the past three decades, atomic force microscopy (AFM) has emerged as a key platform enabling the simultaneous morphological and mechanical characterization of living biological systems. In this Review, we survey the basic principles, advantages and limitations of the most common AFM modalities used to map the dynamic mechanical properties of complex biological samples to their morphology. We discuss how mechanical properties can be directly linked to function, which has remained a poorly addressed issue. We outline the potential of combining AFM with complementary techniques, including optical microscopy and spectroscopy of mechanosensitive fluorescent constructs, super-resolution microscopy, the patch clamp technique and the use of microstructured and fluidic devices to characterize the 3D distribution of mechanical responses within biological systems and to track their morphology and functional state.
CitationKrieg, M. [et al.]. Atomic force microscopy-based mechanobiology. "Nature Reviews Physics volume", 1 Novembre 2018, vol. 1, p. 41-57. 
URIhttp://hdl.handle.net/2117/173416
DOI10.1038/ s42254-018-0001-7
Publisher versionhttps://www.nature.com/articles/s42254-018-0001-7
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