Recent Submissions

  • Neural engineering with photons as synaptic transmitters 

    Porta-de-la-Riva, Montserrat; Gonzalez, Adriana Carolina; Sanfeliu-Cerdán, Neus; Karimi, Shadi; Malaiwong, Nawaphat; Pidde, Aleksandra; Morales-Curiel, Luis-Felipe; Fernandez, Pablo; González-Bolívar, Sara; Hurth, Cedric; Krieg, Michael (Nature methods, 2023-04-06)
    Article
    Open Access
    Neuronal computation is achieved through connections of individual neurons into a larger network. To expand the repertoire of endogenous cellular communication, we developed a synthetic, photon-assisted synaptic transmission ...
  • Understanding neural circuit function through synaptic engineering 

    Rabinowitch, Ithai; Colón-Ramos, Daniel A.; Krieg, Michael (Nature reviews neuroscience, 2024-01-03)
    Article
    Open Access
    Synapses are a key component of neural circuits, facilitating rapid and specific signalling between neurons. Synaptic engineering — the synthetic insertion of new synaptic connections into in vivo neural circuits — is an ...
  • Neuronal stretch reception – making sense of the mechanosense 

    Das, Ravi; Wieser, Stefan; Krieg, Michael (Elsevier, 2019-05-01)
    Article
    Open Access
    The sensation of mechanical force underlies many of our daily activities. As the sense of touch determines the quality of life, the subconscious sense of proprioception and visceral mechanosensation is indispensible for ...
  • Rationally designed azobenzene photoswitches for efficient two-photon neuronal excitation 

    Cabré, Gisela; Garrido-Charle, Aida; Moreno, Miquel; Bosch, Miquel; Porta-de-la-Riva, Montserrat; Krieg, Michael; Gascón-Moya, Marta; Camarero, Núria; Gelabert, Ricard; Lluch, José M.; Busqué, Félix; Hernando, Jordi; Gorostiza, Pau; Alibés, Ramon (Nature, 2019-02-22)
    Article
    Open Access
    Manipulation of neuronal activity using two-photon excitation of azobenzene photoswitches with near-infrared light has been recently demonstrated, but their practical use in neuronal tissue to photostimulate individual ...
  • Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc 

    He, Liping; Gulyanon, Sarun; Skanata, Mirna Mihovilovic; Karagyozov, Doycho; Heckscher, Ellie S.; Krieg, Michae; Tsechpenakis, Gavriil; Gershow, Marc; W. Daniel, Tracey, Jr (Sciencedirect, 2019-03-01)
    Article
    Open Access
    Drosophila Transmembrane channel-like (Tmc) is a protein that functions in larval proprioception. The closely related TMC1 protein is required for mammalian hearing and is a pore-forming subunit of the hair cell ...
  • Atomic force microscopy-based mechanobiology 

    Krieg, Michael; Fläschner, Gotthold; Alsteens, David; Gaub, Benjamin M.; Roos, Wouter H.; Wuite, Gijs J. L.; Gaub, Hermann E.; Gerber, Christoph; Dufrêne, Yves F; Mülle, Daniel J. (Nature, 2018-11-01)
    Article
    Open Access
    Mechanobiology emerges at the crossroads of medicine, biology, biophysics and engineering and describes how the responses of proteins, cells, tissues and organs to mechanical cues contribute to development, differentiation, ...