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Network-based enrichment analysis of gene expression through protein-protein interaction data

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10.1109/EMBC.2012.6347438
 
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hdl:2117/17221

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Massanet Vila, Raimon
Fernández Albert, Francesc
Caminal Magrans, PereMés informacióMés informació
Perera Lluna, AlexandreMés informacióMés informacióMés informació
Document typeConference report
Defense date2012
PublisherIEEE
Rights accessRestricted access - publisher's policy
All rights reserved. This work is protected by the corresponding intellectual and industrial property rights. Without prejudice to any existing legal exemptions, reproduction, distribution, public communication or transformation of this work are prohibited without permission of the copyright holder
Abstract
High-throughput analysis of gene expression data is subject to technological and statistical issues that confuse the underlying expression-condition associations. In this contribution a network-based candidate gene prioritization strategy was applied to the enrichment of a publicly available gene expression dataset, focused on the study of the mechanosensitivity of genes exposed to altered pulmonary matrix stiffness. Results suggested that some genes which had not been taken into account in the original study could have an important role in the processes causing, or affected by, pulmonary fibrosis.
CitationMassanet, R. [et al.]. Network-based enrichment analysis of gene expression through protein-protein interaction data. A: IEEE Engineering in Medicine and Biology Society. "34th Annual International Conference of the IEEE EMBS San Diego, California USA, 28 August-1 September, 2012". San Diego, California: IEEE, 2012, p. 6317-6320. 
URIhttp://hdl.handle.net/2117/17221
DOI10.1109/EMBC.2012.6347438
ISBN978-1-4577-1787-1/12
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  • Departament d'Enginyeria de Sistemes, Automàtica i Informàtica Industrial - Ponències/Comunicacions de congressos [1.391]
  • SISBIO - Senyals i Sistemes Biomèdics - Ponències/Comunicacions de congressos [98]
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