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dc.contributor.authorPuiggalí Jou, Anna
dc.contributor.authorValle Mendoza, Luis Javier del
dc.contributor.authorAlemán Llansó, Carlos
dc.contributor.otherUniversitat Politècnica de Catalunya. Doctorat en Enginyeria Biomèdica
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2019-11-06T09:26:14Z
dc.date.available2019-11-06T09:26:14Z
dc.date.issued2019-08-01
dc.identifier.citationPuiggali, A.; del Valle, LJ.; Aleman, C. Cell responses to electrical pulse stimulation for anticancer drug release. "Materials", 1 Agost 2019, vol. 12, núm. 16, p. 2633:1-2633:15.
dc.identifier.issn1996-1944
dc.identifier.urihttp://hdl.handle.net/2117/171811
dc.description.abstractElectrical stimulation is an attractive approach to tune on-demand drug release in the body as it relies on simple setups and requires typically 1 V or less. Although many studies have been focused on the development of potential smart materials for electrically controlled drug release, as well as on the exploration of different delivery mechanisms, progress in the field is slow because the response of cells exposed to external electrical stimulus is frequently omitted from such investigations. In this work, we monitor the behavior of prostate and breast cancer cells (PC-3 and MCF7, respectively) exposed to electroactive platforms loaded with curcumin, a hydrophobic anticancer drug. These consist in conducting polymer nanoparticles, which release drug molecules by altering their interactions with polymer, and electrospun polyester microfibres that contain electroactive nanoparticles able to alter the porosity of the matrix through an electro-mechanical actuation mechanism. The response of the cells against different operating conditions has been examined considering their viability, metabolism, spreading and shape. Results have allowed us to differentiate the damage induced in the cell by the electrical stimulation from other effects, as for example, the anticancer activity of curcumin and/or the presence of curcumin-loaded nanoparticles or fibres, demonstrating that these kinds of platforms can be effective when the dosage of the drug occurs under restricted conditions
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshConducting polymers
dc.subject.lcshCopolymers
dc.subject.lcshMedical electronics
dc.subject.lcshNanoparticles
dc.subject.otherAnticancer activity
dc.subject.otherCell damage
dc.subject.otherConducting polymer
dc.subject.otherDrug delivery
dc.subject.otherElectrostimulation
dc.subject.otherNanoparticles
dc.subject.otherPolycaprolactone
dc.subject.otherPolyesters
dc.titleCell responses to electrical pulse stimulation for anticancer drug release
dc.typeArticle
dc.subject.lemacPolímers conductors
dc.subject.lemacCopolímers
dc.subject.lemacElectrònica mèdica
dc.subject.lemacNanopartícules
dc.contributor.groupUniversitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies
dc.contributor.groupUniversitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables.
dc.identifier.doi10.3390/ma12162633
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttps://www.mdpi.com/1996-1944/12/16/2633
dc.rights.accessOpen Access
local.identifier.drac25820158
dc.description.versionPostprint (author's final draft)
local.citation.authorPuiggali, A.; del Valle, LJ.; Aleman, C.
local.citation.publicationNameMaterials
local.citation.volume12
local.citation.number16
local.citation.startingPage2633:1
local.citation.endingPage2633:15


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Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain