Mostra el registre d'ítem simple
Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols
dc.contributor.author | Rocasalbas Lozano, Guillem |
dc.contributor.author | Francesko, Antonio |
dc.contributor.author | Touriño Eirín, Sonia |
dc.contributor.author | Fernández Francos, Xavier |
dc.contributor.author | Guebitz, Georg M. |
dc.contributor.author | Tzanov, Tzanko |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2012-12-12T10:28:13Z |
dc.date.created | 2012-11-02 |
dc.date.issued | 2013-02-15 |
dc.identifier.citation | Rocasalbas, G. [et al.]. Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols. "Carbohydrate polymers", 15 Febrer 2013, vol. 92, núm. 2, p. 989-996. |
dc.identifier.issn | 0144-8617 |
dc.identifier.uri | http://hdl.handle.net/2117/17113 |
dc.description.abstract | Laccase-assisted simultaneous cross-linking and functionalization of chitosan/gelatin blends with phenolic compounds from Hamamelis virginiana was investigated for the development of bioactive hydrogel dressings. The potential of these hydrogels for chronic wound treatment was evaluated in vitro, assessing their antibacterial and inhibitory effect on myeloperoxidase and collagenase. Rheological studies revealed that the mechanical properties of the hydrogels were a function of the enzymatic reaction time. Stable hydrogels and resistant to lysozyme degradation were achieved after 2 h laccase reaction. The inhibitory capacity of the hydrogel for myeloperoxidase and collagenase was 32% and 79% respectively after 24 h incubation. Collagenase activity was additionally suppressed by adsorption (20%) of the enzyme onto the hydrogel. Therefore, the bioactive properties of the hydrogels were due to the effect of both released phenolic compounds and the permanently functionalized platform itself. The hydrogels showed antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus. |
dc.format.extent | 8 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Biotechnology |
dc.title | Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols |
dc.type | Article |
dc.subject.lemac | Biotecnologia |
dc.contributor.group | Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial |
dc.identifier.doi | 10.1016/j.carbpol.2012.10.045 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0144861712010739# |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 11014226 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Rocasalbas, G.; Francesko, A.; Touriño, S.; Fernández, X.; Guebitz, G.; Tzanov, T. |
local.citation.publicationName | Carbohydrate polymers |
local.citation.volume | 92 |
local.citation.number | 2 |
local.citation.startingPage | 989 |
local.citation.endingPage | 996 |
Fitxers d'aquest items
Aquest ítem apareix a les col·leccions següents
-
Articles de revista [189]
-
Articles de revista [2.212]