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dc.contributor.authorRocasalbas Lozano, Guillem
dc.contributor.authorFrancesko, Antonio
dc.contributor.authorTouriño Eirín, Sonia
dc.contributor.authorFernández Francos, Xavier
dc.contributor.authorGuebitz, Georg M.
dc.contributor.authorTzanov, Tzanko
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2012-12-12T10:28:13Z
dc.date.created2012-11-02
dc.date.issued2013-02-15
dc.identifier.citationRocasalbas, G. [et al.]. Laccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols. "Carbohydrate polymers", 15 Febrer 2013, vol. 92, núm. 2, p. 989-996.
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/2117/17113
dc.description.abstractLaccase-assisted simultaneous cross-linking and functionalization of chitosan/gelatin blends with phenolic compounds from Hamamelis virginiana was investigated for the development of bioactive hydrogel dressings. The potential of these hydrogels for chronic wound treatment was evaluated in vitro, assessing their antibacterial and inhibitory effect on myeloperoxidase and collagenase. Rheological studies revealed that the mechanical properties of the hydrogels were a function of the enzymatic reaction time. Stable hydrogels and resistant to lysozyme degradation were achieved after 2 h laccase reaction. The inhibitory capacity of the hydrogel for myeloperoxidase and collagenase was 32% and 79% respectively after 24 h incubation. Collagenase activity was additionally suppressed by adsorption (20%) of the enzyme onto the hydrogel. Therefore, the bioactive properties of the hydrogels were due to the effect of both released phenolic compounds and the permanently functionalized platform itself. The hydrogels showed antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus.
dc.format.extent8 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshBiotechnology
dc.titleLaccase-assisted formation of bioactive chitosan/gelatin hydrogel stabilized with plant polyphenols
dc.typeArticle
dc.subject.lemacBiotecnologia
dc.contributor.groupUniversitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.identifier.doi10.1016/j.carbpol.2012.10.045
dc.description.peerreviewedPeer Reviewed
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0144861712010739#
dc.rights.accessRestricted access - publisher's policy
local.identifier.drac11014226
dc.description.versionPostprint (published version)
dc.date.lift10000-01-01
local.citation.authorRocasalbas, G.; Francesko, A.; Touriño, S.; Fernández, X.; Guebitz, G.; Tzanov, T.
local.citation.publicationNameCarbohydrate polymers
local.citation.volume92
local.citation.number2
local.citation.startingPage989
local.citation.endingPage996


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