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Block and graft copolymers made of 16-membered macrolactones and l-Alanine: a comparative study
dc.contributor.author | Tinajero, Ernesto |
dc.contributor.author | Martínez de Ilarduya Sáez de Asteasu, Domingo Antxon |
dc.contributor.author | Muñoz Guerra, Sebastián |
dc.contributor.other | Universitat Politècnica de Catalunya. Doctorat en Polímers i Biopolímers |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2019-10-22T08:09:13Z |
dc.date.available | 2020-08-14T00:33:15Z |
dc.date.issued | 2019-08-01 |
dc.identifier.citation | Tinajero, E.; Martinez de Ilarduya, A.; Muñoz, S. Block and graft copolymers made of 16-membered macrolactones and l-Alanine: a comparative study. "Macromolecular chemistry and physics", 1 Agost 2019, vol. 220, núm. 17, p. 1900214:1-1900214:32. |
dc.identifier.issn | 1022-1352 |
dc.identifier.uri | http://hdl.handle.net/2117/170540 |
dc.description.abstract | Block and graft poly(macrolactone)-poly(a-amino acid) copolymers made of l-alanine and pentadecalactone or globalide respectively, are prepared. A sequential ring-opening polymerization (ROP) copolymerization route consisting of two stages, the first devoted to the preparation of the amino-functionalized poly(macrolactone) and the second to the amino-initiated polymerization of l-alanine N-carboxyanhydride (Ala-NCA), is followed for the synthesis of both types of copolymers. Poly(l-alanine) segment lengths are accurately controlled by adjusting the macroitiator/Ala-NCA ratio used for reaction in the second stage. Block copolymers are semicrystalline with the poly(pentadecalactone) block crystallizes well in a separate phase and the poly(a-amino acid) block arranged in either the a-helical or ß-sheet structure in a ratio that is depending on composition and temperature. Graft copolymers are amorphous but with the poly(a-amino acid) side chains arranged in a more or less regular conformation. Nanoparticles with a diameter of around 300 nm and moderate positive Z-potential can be obtained from the block copolymers by self-assembling in water whereas graft copolymers are unable to render recognizable objects of nanometer-dimension under similar conditions. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Block copolymers |
dc.subject.lcsh | Copolymers |
dc.subject.lcsh | Polypeptides |
dc.subject.other | Block copolymers |
dc.subject.other | Graft copolymers |
dc.subject.other | Polymacrolactones |
dc.subject.other | Polypeptides |
dc.title | Block and graft copolymers made of 16-membered macrolactones and l-Alanine: a comparative study |
dc.type | Article |
dc.subject.lemac | Copolímers de bloc |
dc.subject.lemac | Copolímers |
dc.subject.lemac | Polipèptids |
dc.contributor.group | Universitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics |
dc.identifier.doi | 10.1002/macp.201900214 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/abs/10.1002/macp.201900214 |
dc.rights.access | Open Access |
local.identifier.drac | 25821448 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Tinajero, E.; Martinez de Ilarduya, A.; Muñoz, S. |
local.citation.publicationName | Macromolecular chemistry and physics |
local.citation.volume | 220 |
local.citation.number | 17 |
local.citation.startingPage | 1900214:1 |
local.citation.endingPage | 1900214:32 |
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