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Antimicrobial activity of poly(3,4-ethylenedioxythiophene) n-doped with a pyridinium-containing polyelectrolyte
dc.contributor.author | Sánchez Jiménez, Margarita |
dc.contributor.author | Estrany Coda, Francesc |
dc.contributor.author | Borràs Cristòfol, Núria |
dc.contributor.author | Maiti, Binoy |
dc.contributor.author | Díaz Díaz, David |
dc.contributor.author | Valle Mendoza, Luis Javier del |
dc.contributor.author | Alemán Llansó, Carlos |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2019-09-26T18:29:37Z |
dc.date.available | 2020-08-30T00:29:35Z |
dc.date.issued | 2019-08-30 |
dc.identifier.citation | Sanchez, M. [et al.]. Antimicrobial activity of poly(3,4-ethylenedioxythiophene) n-doped with a pyridinium-containing polyelectrolyte. "Soft matter", 30 Agost 2019, vol.15, num.38, p. 7695-7703 |
dc.identifier.issn | 1744-683X |
dc.identifier.uri | http://hdl.handle.net/2117/168783 |
dc.description.abstract | In spite of p-doped conducting polymers having been widely studied in the last decades and many applications having been developed, studies based on n-doped conducting polymers are extremely scarce. This fact is even more evident when it comes to conducting polymers n-doped with polycations, even though polyanions, such as poly(styrenesulfonate), are often used to obtain p-doped conducting polymers. In this work poly(pyridinium-1,4-diyliminocarbonyl-1,4-phenylene-methylene chloride), abbreviated as P(Py-1,4-P), has been used to prepare n-doped poly(3,4-ethylenedioxythiophene) (PEDOT) electrodes by applying a reduction potential to a de-doped PEDOT film in a P(Py-1,4-P) water solution. The utilization of this cationic polyelectrolyte as an n-dopant agent results in drastic superficial changes, as is observed by comparing the morphology, topography and wettability of p-doped, de-doped and n-doped PEDOT. Cytotoxicity, cell adhesion and cell proliferation assays, which have been conducted using epithelial and fibroblast cell lines, show that the amount of P(Py-1,4-P) in the re-doped PEDOT films is below that required to observe a cytotoxic harmful response and that n-doped PEDOT:P(Py-1,4-P) films are biocompatible. The non-specific bacteriostatic properties of n-doped PEDOT:P(Py-1,4-P) films have been demonstrated against E. coli and S. aureus bacteria (Gram-negative and Gram-positive, respectively) using bacterial growth curves and adhesion assays. Although the bacteriostatic effect is in part due to the conducting polymer, as is proved by results for p-doped and de-doped PEDOT, the incorporation of P(Py-1,4-P) through the re-doping process greatly enhances this antimicrobial behaviour. Thus, only a small concentration of this cationic polyelectrolyte (~0.1 mM) is needed to inhibit bacterial growth. |
dc.format.extent | 27 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química::Química física::Electroquímica |
dc.subject.lcsh | Conducting polymers |
dc.subject.lcsh | Plastic films |
dc.title | Antimicrobial activity of poly(3,4-ethylenedioxythiophene) n-doped with a pyridinium-containing polyelectrolyte |
dc.type | Article |
dc.subject.lemac | Polielectrolits |
dc.subject.lemac | Polímers conductors |
dc.subject.lemac | Pel·lícules de plàstic |
dc.contributor.group | Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies |
dc.contributor.group | Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables |
dc.identifier.doi | 10.1039/C9SM01491H |
dc.relation.publisherversion | https://pubs.rsc.org/en/content/articlelanding/2019/sm/c9sm01491h#!divAbstract |
dc.rights.access | Open Access |
local.identifier.drac | 25840802 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Sanchez, M.; Estrany, F.; Borras, N.; Maiti, B.; Díaz-Díaz, D.; del Valle, LJ.; Aleman, C. |
local.citation.publicationName | Soft matter |
local.citation.volume | 15 |
local.citation.number | 38 |
local.citation.startingPage | 7695 |
local.citation.endingPage | 7703 |
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