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Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological Chaperone that Increases the Activity of Misfolded ß-Glucocerebrosidase
dc.contributor.author | Enshaei, Hamidreza |
dc.contributor.author | Molina, Brenda G. |
dc.contributor.author | Valle Mendoza, Luis Javier del |
dc.contributor.author | Estrany Coda, Francesc |
dc.contributor.author | Arnan, Carme |
dc.contributor.author | Puiggalí Bellalta, Jordi |
dc.contributor.author | Saperas Plana, Núria |
dc.contributor.author | Alemán Llansó, Carlos |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2019-09-26T08:19:59Z |
dc.date.available | 2020-06-21T00:26:44Z |
dc.date.issued | 2019-01-01 |
dc.identifier.citation | Enshaei, H. [et al.]. Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological Chaperone that Increases the Activity of Misfolded ß-Glucocerebrosidase. "Macromolecular bioscience (Internet)", 1 Gener 2019, vol. 19, núm. 8, p. 1900130. |
dc.identifier.issn | 1616-5195 |
dc.identifier.uri | http://hdl.handle.net/2117/168717 |
dc.description.abstract | Ambroxol is a pharmacological chaperone (PC) for Gaucher disease that increases lysosomal activity of misfolded ß-glucocerebrosidase (GCase) while displaying a safe toxicological profile. In this work, different poly(e-caprolactone) (PCL)-based systems are developed to regulate the sustained release of small polar drugs in physiological environments. For this purpose, ambroxol is selected as test case since the encapsulation and release of PCs using polymeric scaffolds have not been explored yet. More specifically, ambroxol is successfully loaded in electrospun PCL microfibers, which are subsequently coated with additional PCL layers using dip-coating or spin-coating. The time needed to achieve 80% release of loaded ambroxol increases from ˜15 min for uncoated fibrous scaffolds to 3 days and 1 week for dip-coated and spin-coated systems, respectively. Furthermore, it is proven that the released drug maintains its bioactivity, protecting GCase against induced thermal denaturation |
dc.format.extent | 12 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria química |
dc.subject.lcsh | Polymers |
dc.subject.lcsh | Biomedical materials |
dc.title | Scaffolds for sustained release of ambroxol hydrochloride, a pharmacological Chaperone that Increases the Activity of Misfolded ß-Glucocerebrosidase |
dc.type | Article |
dc.subject.lemac | Polímers |
dc.subject.lemac | Materials biomèdics |
dc.contributor.group | Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables |
dc.contributor.group | Universitat Politècnica de Catalunya. IMEM-BRT- Innovation in Materials and Molecular Engineering - Biomaterials for Regenerative Therapies |
dc.contributor.group | Universitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques |
dc.identifier.doi | 10.1002/mabi.201900130 |
dc.description.peerreviewed | Peer Reviewed |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.201900130 |
dc.rights.access | Open Access |
local.identifier.drac | 25501943 |
dc.description.version | Postprint (author's final draft) |
local.citation.author | Enshaei, H.; Molina, B.; del Valle, LJ.; Estrany, F.; Arnan, C.; Puiggali, J.; Saperas, N.; Aleman, C. |
local.citation.publicationName | Macromolecular bioscience (Internet) |
local.citation.volume | 19 |
local.citation.number | 8 |
local.citation.startingPage | 1900130:1 |
local.citation.endingPage | 190013012 |
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