Show simple item record

dc.contributor.authorFonfria Subirós, Elsa
dc.contributor.authorAcosta Reyes, Francisco Javier
dc.contributor.authorSaperas Plana, Núria
dc.contributor.authorPous, Joan
dc.contributor.authorSubirana Torrent, Juan A.
dc.contributor.authorCampos López, Josefina de Lourdes
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2012-10-05T10:27:05Z
dc.date.available2012-10-05T10:27:05Z
dc.date.created2012-05-16
dc.date.issued2012-05-16
dc.identifier.citationFonfria, E. [et al.]. Crystal structure of a complex of DNA with one AT-hook of HMGA1. "PLoS One", 16 Maig 2012, vol. 7, núm. 5, p. 1-5.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/2117/16654
dc.description.abstractWe present here for the first time the crystal structure of an AT-hook domain. We show the structure of an AT-hook of the ubiquitous nuclear protein HMGA1, combined with the oligonucleotide d(CGAATTAATTCG)2, which has two potential AATT interacting groups. Interaction with only one of them is found. The structure presents analogies and significant differences with previous NMR studies: the AT-hook forms hydrogen bonds between main-chain NH groups and thymines in the minor groove, DNA is bent and the minor groove is widened.
dc.format.extent5 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria química
dc.subject.lcshDNA
dc.titleCrystal structure of a complex of DNA with one AT-hook of HMGA1
dc.typeArticle
dc.subject.lemacCristal·lografia
dc.subject.lemacADN
dc.contributor.groupUniversitat Politècnica de Catalunya. MACROM - Cristal·lografia, Estructura i Funció de Macromolècules Biològiques
dc.identifier.doi10.1371/journal.pone.0037120
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037120
dc.rights.accessOpen Access
local.identifier.drac10509906
dc.description.versionPostprint (published version)
local.citation.authorFonfria, E.; Acosta, F.J.; Saperas, N.; Pous, J.; Subirana, J.; Campos, J.L
local.citation.publicationNamePLoS One
local.citation.volume7
local.citation.number5
local.citation.startingPage1
local.citation.endingPage5
dc.identifier.pmid22615915


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record