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Mathematical models for drug delivery from textile

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Martí Gelabert, Meritxell
Martínez, Vanessa
Lis Arias, Manuel JoséMés informacióMés informacióMés informació
Coderch Negra, Luisa
Document typeArticle
Defense date2019-06-24
Rights accessOpen Access
Attribution-NonCommercial 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial 3.0 Spain
Abstract
Gallic acid was microencapsulated in poly-¿-caprolactone by the solvent evaporation method and was applied onto biofunctional textile substrates, cotton, and polyamide fabrics using a finishing process. A higher content of microspheres on polyamide was obtained due to the more hydrophobic character of polyamide. Drug release in physiological serum was carried out with treated fabrics submerged into a thermostatized vessel at semi-infinite bath conditions. The kinetic study carried out allowed the determination of the drug-delivery behavior for all systems in the medium. The results showed that the hydrophobicity and affinity of textiles and gallic acid influenced the release mechanism. For cotton, a clear Fickian diffusion was obtained; for polyamide, the diffusion was anomalous. However, no differences were found in the global mass transport. The model could address the need of the medical and health sector for assessing the theoretical amount of drug released from biofunctional textile
CitationMartí, M. [et al.]. Mathematical models for drug delivery from textile. "Journal of Industrial Textiles", 2021, vol. 50, núm. 8, p. 1225-1238 
URIhttp://hdl.handle.net/2117/166363
DOI10.1177/1528083719858769
ISSN1528-0837
Publisher versionhttps://journals.sagepub.com/doi/abs/10.1177/1528083719858769
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