Evaluation of the prognosis of HPV negative but p16 positive oropharyngeal cancer patients in an international collaborative study (EPIC-OPC).

Abstract

Some studies have reported that the outcome of the patients with HPV positive and p16 negative is significantly worse than the outcomes of patients who are HPV positive and p16 positive. The aim of this study is to increase the number of the cases HPV-negative/p16-positive since most cohorts had amassed relatively few cases, and to clearly define the prognosis of these patients and describe their characteristics in terms of age, gender, TNM stage and other variables. To this end, chi-square test of independence and multinomial logistic regressions with random effects were used.