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Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue
dc.contributor.author | Peñaranda Ayllón, Angelina |
dc.contributor.author | Rodríguez Cantalapiedra, Inma |
dc.contributor.author | Echebarría Domínguez, Blas |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament de Física Aplicada |
dc.date.accessioned | 2012-07-11T08:17:23Z |
dc.date.created | 2010 |
dc.date.issued | 2010 |
dc.identifier.citation | Peñaranda, A.; Cantalapiedra, I. R.; Echebarria, B. Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue. A: Computing in Cardiology. "Computing in Cardiology 2010: scientific program". Belfast: 2010, p. 661-664. |
dc.identifier.uri | http://hdl.handle.net/2117/16221 |
dc.description.abstract | Phase-2 reentry is a basic mechanism for the transition to VT and VF in the heart. It is thought to underly many causes of idiopathic ventricular arrhythmias as, for instance, those occurring in Brugada syndrome. Reentry is usually linked to heterogeneity in tissue repolarization. We study some circunstances under which a region of depolarized tissue can reexcite adjacent regions that exhibit shorter action potential duration (APD), eventually inducing reentry. Simulations are performed using a simplified ionic model that reproduces well the ventricular action potential (AP). We analyze first the conditions that lead to very short action potentials (APs). Then, we show that reexcitation takes place via a slow (calcium current induced) pulse that propagates into the region of short APs until it encounters excitable tissue. In two dimensions, this may give rise to reentry with the formation of counter-rotating spiral waves |
dc.format.extent | 4 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Física |
dc.subject.lcsh | Bioelectronics |
dc.subject.lcsh | Physics |
dc.title | Slow pulse due to calcium current induces phase-2 reentry in heterogeneous tissue |
dc.type | Conference report |
dc.subject.lemac | Bioelectrònica |
dc.subject.lemac | Física |
dc.contributor.group | Universitat Politècnica de Catalunya. GICITED - Grup Interdiciplinari de Ciència i Tecnologia en l'Edificació |
dc.contributor.group | Universitat Politècnica de Catalunya. NOLIN - Física No-Lineal i Sistemes Fora de l'Equilibri |
dc.relation.publisherversion | http://www.cinc.org/archives/2010/pdf/0661.pdf |
dc.rights.access | Restricted access - publisher's policy |
local.identifier.drac | 5281949 |
dc.description.version | Postprint (published version) |
dc.date.lift | 10000-01-01 |
local.citation.author | Peñaranda, A.; Cantalapiedra, I. R.; Echebarria, B. |
local.citation.contributor | Computing in Cardiology |
local.citation.pubplace | Belfast |
local.citation.publicationName | Computing in Cardiology 2010: scientific program |
local.citation.startingPage | 661 |
local.citation.endingPage | 664 |