This article seeks to presentmethods for preventing work-relatedmusculoskeletal disorders of Spanish fishermen and for redesigning the workplace aboard small fishing vessels. To achieve its objective, the research project was designed in four steps. First, the equipment and procedures for catching, handling, and storing fish were studied. Second, the work postures of all the fishermen were simulated and assessed by using an ergonomic digital human modeling system (ManneQuin Pro). Third, the work environment design aboard vessels was modified on the basis of acceptable simulated work postures to prevent repetitive movements, awkward working postures, and lower back biomechanical stresses. In the fourth step, ergonomic design parameters were provided to vessel designers.