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dc.contributor.authorBarrio Casado, María del
dc.contributor.authorMaccaroni, Elisabetta
dc.contributor.authorRietveld, Ivo B.
dc.contributor.authorMacpezzi, Luciana
dc.contributor.authorMasciocchi, Norberto
dc.contributor.authorCéolin, René
dc.contributor.authorTamarit Mur, José Luis
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
dc.date.accessioned2012-01-20T11:16:26Z
dc.date.available2012-01-20T11:16:26Z
dc.date.created2011-11-03
dc.date.issued2011-11-03
dc.identifier.citationDel Barrio, M. [et al.]. Pressure–temperature state diagram for the phase relationships between benfluorex hydrochloride forms I and II: A case of enantiotropic behavior. "Journal of pharmaceutical sciences", 03 Novembre 2011, vol. 101, núm. 3, p. 1072-1078.
dc.identifier.issn0022-3549
dc.identifier.urihttp://hdl.handle.net/2117/14696
dc.description.abstractThe active pharmaceutical ingredient racemic benfluorex hydrochloride (benfluorex–HCl) has an interesting phase behavior due to an elusive solid–solid phase transition. The stability hierarchy between different phases is often determined based on heat-related experiments only or slurry interconversion. It is shown that if pressure and volume are taken into account, not only the phase equilibria are correctly positioned in the pressure–temperature phase diagram, but the experimental data also improves. Thus, it has been found that the racemic benfluorex–HCl is enantiotropic under “ordinary conditions” with polymorph II and polymorph I, respectively, being the low- and the high-temperature phases. Above ∼151 MPa, the system becomes monotropic and polymorph II is the single stable phase.
dc.format.extent7 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Física::Física de l'estat sòlid
dc.subject.lcshCalorimetry
dc.subject.lcshThermodynamics
dc.subject.lcshThermal analysis
dc.subject.lcshSolid state
dc.titlePressure–temperature state diagram for the phase relationships between benfluorex hydrochloride forms I and II: A case of enantiotropic behavior
dc.typeArticle
dc.subject.lemacTermodinàmica
dc.subject.lemacColorimetria
dc.contributor.groupUniversitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.identifier.doi10.1002/jps.22821
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/jps.22821/pdf
dc.rights.accessRestricted access - publisher's policy
drac.iddocument9412007
dc.description.versionPostprint (published version)
upcommons.citation.authorDel Barrio, M.; Maccaroni, E.; Rietveld, I.; Macpezzi, L.; Masciocchi, N.; Céolin, R.; Tamarit, J.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameJournal of pharmaceutical sciences
upcommons.citation.volume101
upcommons.citation.number3
upcommons.citation.startingPage1072
upcommons.citation.endingPage1078


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