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dc.contributor.authorTeulon, Jean-Marie
dc.contributor.authorMahé, Nathalie
dc.contributor.authorDo, Bernard
dc.contributor.authorNicolaï, Béatrice
dc.contributor.authorRietveld, Ivo B.
dc.contributor.authorBarrio Casado, María del
dc.contributor.authorTamarit Mur, José Luis
dc.contributor.authorCéolin, René
dc.contributor.authorGhéchot, Christophe
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Física i Enginyeria Nuclear
dc.identifier.citationMahé, N. [et al.]. Crystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension. "International journal of pharmaceutics", 2012, vol. 422, núm. 1-2, p. 47-51.
dc.description.abstractAging of drug molecules is generally studied following regulatory procedures, i.e. under forced conditions and for relatively limited storage time; therefore naturally aged samples are rare and provide scientific reference data beyond regulatory considerations. Tienoxolol was studied after 25 years of storage in the dark under ambient conditions. About 86% of the samples still consisted of tienoxolol and the main impurity (13%) was caused by the hydrolysis of the ester moiety. Protection from humidity is therefore important. Other sensitive groups containing nitrogen and sulfur appear to be quite stable with less than 0.8% conversion over 25 years. In addition, the crystal structure has been solved. Tienoxolol orange needles were found to crystallize in the orthorhombic non-centrosymmetric space group Iba2, indicating that the crystal is a racemic compound. The unit cell parameters at room temperature are a = 10.069(5)A˚ , b = 45.831(10)A˚ , and c = 9.822(5) ˚A and the unit cell volume is 4533(3) ˚A3 with Z = 8. © 2011 Elsevier B.V.
dc.format.extent5 p.
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.subjectÀrees temàtiques de la UPC::Ciències de la salut::Medicina::Farmacologia
dc.subjectÀrees temàtiques de la UPC::Física::Física de l'estat sòlid
dc.subject.lcshHypertension Age factors
dc.subject.lcshX-ray diffractometer
dc.titleCrystal structure and solid-state studies of aged samples of tienoxolol, an API designed against hypertension
dc.subject.lemacIndústria farmacèutica -- Investigació
dc.subject.lemacFísica de l'estat sòlid
dc.contributor.groupUniversitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.rights.accessRestricted access - publisher's policy
dc.description.versionPostprint (published version)
local.citation.authorMahé, N.; Do, B.; Nicolaï, B.; Rietveld, I.; Del Barrio, M.; Tamarit, J.; Céolin, R.; Ghéchot, C.; Teulon, J.
local.citation.publicationNameInternational journal of pharmaceutics

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