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Definition of the viral targets of protective HIV-1-specific T cell responses
dc.contributor.author | Pérez-Alvarez, Susana |
dc.contributor.author | Mothe, Beatriz |
dc.contributor.author | Llano, Anuska |
dc.contributor.author | Ibarrondo, Javier |
dc.contributor.author | Daniels, Marcus |
dc.contributor.author | Miranda, Cristina |
dc.contributor.author | Zamarreño, Jennifer |
dc.contributor.author | Bach, Vanessa |
dc.contributor.author | Zuniga, Rosario |
dc.contributor.author | Brander, C. |
dc.contributor.author | Sanchez, Jorge |
dc.contributor.author | Brumme, Chanson J. |
dc.contributor.author | Sánchez-Merino, Victor |
dc.contributor.author | Yang, Otto O. |
dc.contributor.author | Hildebrand, William H. |
dc.contributor.author | Szinger, James J. |
dc.contributor.author | Farfan, Marilu |
dc.contributor.author | Rolland, Morgane |
dc.contributor.author | Martínez-Picado, Javier |
dc.contributor.author | Puertas, Maria C. |
dc.contributor.author | Berger, Chistoph T. |
dc.contributor.author | Brumme, Zabrina L. |
dc.contributor.author | Korber, Bette T. |
dc.contributor.author | Gatell, Jose M. |
dc.contributor.author | Clotet, Bonaventura |
dc.contributor.author | Goulder, Philip J. |
dc.contributor.author | Walker, Bruce D. |
dc.contributor.author | Mullins, James I. |
dc.contributor.author | Gómez Melis, Guadalupe |
dc.contributor.author | Heckerman, David |
dc.contributor.author | Allen, Todd M. |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa |
dc.date.accessioned | 2012-01-04T17:29:01Z |
dc.date.available | 2012-01-04T17:29:01Z |
dc.date.created | 2011-12-07 |
dc.date.issued | 2011-12-07 |
dc.identifier.citation | Mothe, B. [et al.]. Definition of the viral targets of protective HIV-1-specific T cell responses. "Journal of translational medicine", 07 Desembre 2011, vol. 9, núm. 208, p. 1-48. |
dc.identifier.issn | 1479-5876 |
dc.identifier.uri | http://hdl.handle.net/2117/14410 |
dc.description.abstract | Background: The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine designs are largely based on viral sequence alignments only, not incorporating experimental data on T cell function and specificity. Methods: Here, 950 untreated HIV-1 clade B or -C infected individuals were tested for responses to sets of 410 overlapping peptides (OLP) spanning the entire HIV-1 proteome. For each OLP, a “protective ratio” (PR) was calculated as the ratio of median viral loads (VL) between OLP nonresponders and responders. Results: For both clades, there was a negative relationship between the PR and the entropy of the OLP sequence. There was also a significant additive effect of multiple responses to beneficial OLP. Responses to beneficial OLP were of significantly higher functional avidity than responses to non-beneficial OLP. They also had superior in-vitro antiviral activities and, importantly, were at least as predictive of individuals’ viral loads than their HLA class I genotypes. Conclusions: The data thus identify immunogen sequence candidates for HIV and provide an approach for T cell immunogen design applicable to other viral infections. |
dc.format.extent | 48 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística aplicada::Estadística biosanitària |
dc.subject.lcsh | Biology |
dc.subject.other | epitope |
dc.subject.other | entropy |
dc.subject.other | immune correlate. |
dc.subject.other | HIV specific CTL |
dc.subject.other | clade B |
dc.subject.other | clade C |
dc.subject.other | HLA |
dc.subject.other | vaccine immunogen design |
dc.subject.other | functional avidity |
dc.title | Definition of the viral targets of protective HIV-1-specific T cell responses |
dc.type | Article |
dc.subject.lemac | Biologia |
dc.contributor.group | Universitat Politècnica de Catalunya. GREMA - Grup de Recerca en Estadística Matemàtica i les seves Aplicacions |
dc.identifier.doi | 10.1186/1479-5876-9-208 |
dc.description.peerreviewed | Peer Reviewed |
dc.subject.ams | Classificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics |
dc.relation.publisherversion | http://www.translational-medicine.com/content/pdf/1479-5876-9-208.pdf |
dc.rights.access | Open Access |
local.identifier.drac | 8760036 |
dc.description.version | Postprint (published version) |
local.citation.author | Mothe, B.; Llano, A.; Ibarrondo, J.; Daniels, M.; Miranda, C.; Zamarreño, J.; Bach, V.; Zuniga, R.; Pérez-Alvarez, S.; Berger, C.; Puertas, M.; Martínez-Picado, J.; Rolland, M.; Farfan, M.; Szinger, J.; H. Hildebrand, W.; Yang, O.; Sánchez-Merino, V.; Brumme, C.; Brumme, Z.; Heckerman, D.; Allen, T.; Mullins, J.; Gómez, G.; Goulder, P.; Walker, B.; Gatell, J.; Clotet, B.; Korber, B.; Sanchez, J.; Brander, C. |
local.citation.publicationName | Journal of translational medicine |
local.citation.volume | 9 |
local.citation.number | 208 |
local.citation.startingPage | 1 |
local.citation.endingPage | 48 |
dc.identifier.pmid | 22152067 |
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