Recent Submissions

• Mercury-induced dark-state instability and photobleaching alterations of the visual G-protein coupled receptor rhodopsin 

  Morillo Cazorla, Margarita; Toledo Gonzalez, Darwin; Pérez González, Juan Jesús; Ramon Portés, Eva; Garriga Solé, Pere (2014-07-01)
  Article
  Restricted access - publisher's policy

  Mercuric compounds were previously shown to affect the visual phototransduction cascade, and this could result in vision impairment. We have analyzed the effect of mercuric chloride on the structure and stability of the ...
• Conformational diversity in contryphans from conus venom: Cis-trans isomerisation and aromatic/proline interactions in the 23-membered ring of a 7-residue peptide disulfide loop 

  Sonti, Rajesh; Gowd, Konkallu Hanumae; Rao, K. N Shashanka; Ragothama, Srinivasarao; Rodríguez García, Alejandro; Pérez González, Juan Jesús; Balaram, Padmanabhan (2013-11-05)
  Article
  Restricted access - publisher's policy

  Conformational diversity or “shapeshifting” in cyclic peptide natu- ral products can, in principle, confer a single molecular entity with the proper- ty of binding to multiple receptors. Conformational equilibria have ...
• Amygdalin analogues inhibit INF-gamma signalling reducing inflammatory response in human keratinocytes (HaCat) 

  Paoletti, Iole; De Gregorio, Vicenza; Baroni, Adone; Tufano, Maria Antonieta; Donnarumma, Giovanna; Pérez González, Juan Jesús (2013-12-02)
  Article
  Restricted access - publisher's policy

  Peptide T (PT), an octapeptide fragment located in the V2 region of the HIV-1 gp120- coating protein, appears to be bene fi cial in the treatment of psoriasis. Our previous investigations suggest that keratinocytes ...
• Computational study of substrates and mediators features of lacasses 

  Delavari, Azar; Pérez González, Juan Jesús (2013-06-10)
  Article
  Restricted access - publisher's policy

  Laccases are enzymes of the family multicopper oxidases, being widely used for biotechnological applications (Canas & Camarero, 2010). The enzymes’ catalytic cycle consists of the oxidation of the substrate with the ...
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  Molecular determinants of the bacterial resistance to fluoroquinolones: A computational study 

  Lupala, Cecylia Severin; Gómez Gutiérrez, Patricia; Pérez González, Juan Jesús (2013-06-13)
  Article
  Open Access

  Abstract: Quinolones constitute a large class of antibacterial agents whose action is mediated through the formation of a ternary complex with DNA and either, DNA Gyrase or topoisomerase IV, resulting in the inhibition ...
• Synthesis, Langmuir and Langmuir-Blodgett films of a calix[7]arene ethyl ester. AFM characterization, subphase influence and molecular modelling 

  Torrent Burgués, Juan; Vocanson, Francis; Pérez González, Juan Jesús; Errachid, Abdhellamid (Elsevier, 2012-05-05)
  Article
  Restricted access - publisher's policy

  Calixarenes are promising compounds to be used as ionophores and for molecular recognition. Their ability to form Langmuir and Langmuir–Blodgett (LB) films is of great interest in order to obtain small sensor devices which ...
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  Randomized tree construction algorithm to explore energy landscapes 

  Jaillet, Leonard Georges; Corcho Sánchez, Francisco José; Pérez González, Juan Jesús; Cortés, Juan (2011-12)
  Article
  Open Access

  We report in the present work a new method for exploring conformational energy landscapes. The method, called T-RRT, combines ideas from statistical physics and robot path planning algorithms. A search tree is constructed ...