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Poly(methyl malate) nanoparticles: formation, degradation, and encapsulation of anticancer drugs

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10.1002/mabi.201100107
 
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hdl:2117/13478

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Lanz, Alberto
García Álvarez, MontserratMés informacióMés informacióMés informació
Portilla Arias, Jose Antonio
Martínez de Ilarduya Sáez de Asteasu, Domingo AntxonMés informacióMés informacióMés informació
Patil, Rameshwar
Holler, Eggehard
Ljubimova, Julia Y.
Muñoz Guerra, SebastiánMés informacióMés informació
Document typeArticle
Defense date2011-10-10
Rights accessRestricted access - publisher's policy
Attribution-NonCommercial-NoDerivs 3.0 Spain
Except where otherwise noted, content on this work is licensed under a Creative Commons license : Attribution-NonCommercial-NoDerivs 3.0 Spain
Abstract
PMLA nanoparticles with diameters of 150–250nm are prepared, and their hydrolytic degradation is studied under physiological conditions. Degradation occurs by hydrolysis of the side chain methyl ester followed by cleavage of the main-chain ester group with methanol and L-malic acid as the final degradation products. No alteration of the cell viability is found after 1 h of incubation, but toxicity increases significantly after 3 d, probably due to the noxious effect of the released methanol. Anticancer drugs temozolomide and doxorubicin are encapsulated in the NPs with 20–40% efficiency, and their release is monitored using in vitro essays. Temozolomide is fully liberated within several hours, whereas doxorubicin is steadily released from the particles over a period of 1 month.
CitationLanz, A. [et al.]. Poly(methyl malate) nanoparticles: formation, degradation, and encapsulation of anticancer drugs. "Macromolecular bioscience", 10 Octubre 2011, vol. 11, núm. 10, p. 1370-1377. 
URIhttp://hdl.handle.net/2117/13478
DOI10.1002/mabi.201100107
ISSN1616-5187
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1002/mabi.201100107/abstract
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  • POL - Polímers Industrials Avançats i Biopolímers Tecnològics - Articles de revista [106]
  • Departament d'Enginyeria Química - Articles de revista [1.989]
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