Poly(methyl malate) nanoparticles: formation, degradation, and encapsulation of anticancer drugs
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Document typeArticle
Defense date2011-10-10
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Abstract
PMLA nanoparticles with diameters of 150–250nm are prepared, and their hydrolytic degradation
is studied under physiological conditions. Degradation occurs by hydrolysis of the side
chain methyl ester followed by cleavage of the main-chain ester group with methanol and
L-malic acid as the final degradation products. No
alteration of the cell viability is found after 1 h of
incubation, but toxicity increases significantly after
3 d, probably due to the noxious effect of the released
methanol. Anticancer drugs temozolomide and doxorubicin
are encapsulated in the NPs with 20–40% efficiency,
and their release is monitored using in vitro
essays. Temozolomide is fully liberated within several
hours, whereas doxorubicin is steadily released from
the particles over a period of 1 month.
CitationLanz, A. [et al.]. Poly(methyl malate) nanoparticles: formation, degradation, and encapsulation of anticancer drugs. "Macromolecular bioscience", 10 Octubre 2011, vol. 11, núm. 10, p. 1370-1377.
ISSN1616-5187
Publisher versionhttp://onlinelibrary.wiley.com/doi/10.1002/mabi.201100107/abstract
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