This paper presents both analysis and comparison of the interval observer–based and set-membership approaches for the state estimation and fault detection (FD) in uncertain linear systems. The considered approaches assume that both state disturbance and measurement noise are modeled in a deterministic context following the unknown but bounded approach. The propagation of uncertainty in the state estimation is bounded through a zonotopic set representation. Both approaches have been mathematically related and compared when used for state estimation and FD. A case study based on a two-tanks system is employed for showing the relationship between both approaches while comparing their performance