Comparison of a low molecular weight and a macromolecular surfactant as foaming agents for injectable self setting hydroxyapatite foams: Polysorbate 80 versus gelatine
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Document typeArticle
Defense date2011-10-10
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Abstract
Hydroxyapatite foams are potential synthetic bone grafting materials or scaffolds for bone tissue engineering.
A novel method to obtain injectable hydroxyapatite foams consists in foaming the liquid phase of a calcium
phosphate cement. In this process, the cement powder is incorporated into a liquid foam, which acts as a
template for macroporosity. After setting, the cement hardens maintaining the macroporous structure of the
foam. In this study a low molecular weight surfactant, Polysorbate 80, and a protein, gelatine, were compared
as foaming agents of a calcium phosphate cement. The foamability of Polysorbate 80 was greater than that of
gelatine, resulting in higher macroporosity in the set hydroxyapatite foam and higher macropore
interconnectivity. Gelatine produced less interconnected foams, especially at high concentrations, due to a
higher liquid foam stability. However it increased the injectability and cohesion of the foamed paste, and
enhanced osteoblastic-like cell adhesion, all of them important properties for bone grafting materials.
CitationMontufar, E. [et al.]. Comparison of a low molecular weight and a macromolecular surfactant as foaming agents for injectable self setting hydroxyapatite foams: Polysorbate 80 versus gelatine. "Materials science and engineering C. Biomimetic and supramolecular systems", 10 Octubre 2011, vol. 31, núm. 7, p. 1498-1504.
ISSN0928-4931
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