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dc.contributor.authorValentín Ruiz, David
dc.contributor.authorRoehr, Charline
dc.contributor.authorPresas Batlló, Alexandre
dc.contributor.authorHeiss, Christian
dc.contributor.authorEgusquiza Estévez, Eduard
dc.contributor.authorBosbach, Wolfram A.
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament de Mecànica de Fluids
dc.date.accessioned2019-05-28T13:01:18Z
dc.date.available2019-05-28T13:01:18Z
dc.date.issued2019-01-21
dc.identifier.citationValentin, D. [et al.]. Experimental and Numerical Design and Evaluation of a Vibration Bioreactor using Piezoelectric Patches. "Sensors", 21 Gener 2019, vol. 19, núm. 2, p. 1-15.
dc.identifier.issn1424-8220
dc.identifier.urihttp://hdl.handle.net/2117/133585
dc.description.abstractn this present study, we propose a method for exposing biological cells to mechanical vibration. The motive for our research was to design a bioreactor prototype in which in-depth in vitro studies about the influence of vibration on cells and their metabolism can be performed. The therapy of cancer or antibacterial measures are applications of interest. In addition, questions about the reaction of neurons to vibration are still largely unanswered. In our methodology, we used a piezoelectric patch (PZTp) for inducing mechanical vibration to the structure. To control the vibration amplitude, the structure could be excited at different frequency ranges, including resonance and non-resonance conditions. Experimental results show the vibration amplitudes expected for every frequency range tested, as well as the vibration pattern of those excitations. These are essential parameters to quantify the effect of vibration on cell behavior. Furthermore, a numerical model was validated with the experimental results presenting accurate results for the prediction of those parameters. With the calibrated numerical model, we will study in greater depth the effects of different vibration patterns for the abovementioned cell types.
dc.format.extent15 p.
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria mecànica::Mecànica de fluids::Màquines hidràuliques i de fluids
dc.subject.lcshBioreactors--Fluid dynamics
dc.subject.lcshFluids
dc.subject.otherBioreactor
dc.subject.otherVibration
dc.subject.otherCell biology
dc.subject.otherPZTp
dc.subject.otherLaser Doppler vibrometer (LDV)
dc.subject.otherUltrasound
dc.subject.otherFinite element method
dc.titleExperimental and Numerical Design and Evaluation of a Vibration Bioreactor using Piezoelectric Patches
dc.typeArticle
dc.subject.lemacMecànica de fluids
dc.contributor.groupUniversitat Politècnica de Catalunya. FLUIDS - Enginyeria de Fluids
dc.identifier.doi10.3390/s19020436
dc.relation.publisherversionhttps://www.mdpi.com/1424-8220/19/2/436
dc.rights.accessOpen Access
drac.iddocument23661470
dc.description.versionPostprint (published version)
upcommons.citation.authorValentin, D.; Roehr, C.; Presas, A.; Heiss, C.; Egusquiza, E.; Bosbach, W. A.
upcommons.citation.publishedtrue
upcommons.citation.publicationNameSensors
upcommons.citation.volume19
upcommons.citation.number2
upcommons.citation.startingPage1
upcommons.citation.endingPage15


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Except where otherwise noted, content on this work is licensed under a Creative Commons license: Attribution-NonCommercial-NoDerivs 3.0 Spain