This paper presents a FTC framework for a Real-Time MPC-based Controller applied to Integrated Urban Drainage and Sanitation Systems (UDSSs) which was proposed in the LIFE EFFIDRAIN project. This project deals with the pollution of surface waters due to CSOs and overflows from UDSSs during wet weather. The main purpose of the proposed FTC framework is to preserve as much as possible, the performance of the MPC-based Controller in terms of operation objectives when anomalies affecting the integrated ICT elements (sensors and actuators) occurs. The performance of the FTC controller has been tested using a realistic case of study.