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Amphiphilic ionic complexes of hyaluronic acid with organophosphonium compounds and their antimicrobial activity
dc.contributor.author | Gamarra Montes, Ana |
dc.contributor.author | Forés Gil, Eva |
dc.contributor.author | Morató Farreras, Jordi |
dc.contributor.author | Muñoz Guerra, Sebastián |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Òptica i Optometria |
dc.contributor.other | Universitat Politècnica de Catalunya. Departament d'Enginyeria Química |
dc.date.accessioned | 2019-04-30T11:14:27Z |
dc.date.available | 2019-10-01T00:25:50Z |
dc.date.issued | 2018-01-01 |
dc.identifier.citation | Gamarra, A. [et al.]. Amphiphilic ionic complexes of hyaluronic acid with organophosphonium compounds and their antimicrobial activity. "International journal of biological macromolecules", 1 Gener 2018, vol. 118, p. 2021-2031. |
dc.identifier.issn | 0141-8130 |
dc.identifier.uri | http://hdl.handle.net/2117/132382 |
dc.description.abstract | Amphiphilic ionic complexes of hyaluronic acid and alkyltrimethylphosphonium soaps with alkyl chains containing even numbers of carbons from 12 to 22 have been produced. The complexes have a nearly stoichiometric composition, are non-water soluble, and are stable to heat up to temperatures above 200¿°C. These complexes are amphiphilic and able to adopt a biphasic structure with the paraffinic and polysaccharide phases ordered arranged with a periodicity ranging between 3 and 5¿nm depending on n. The paraffinic phase in complexes with n¿=¿18 was crystallized and showed melting at temperatures between 58 and 70¿°C depending on the n value. The complexes decomposed upon incubation in water under physiological conditions, and undergone extensive biodegradation by the action of hyaluronidases. Biocide assays carried out in both solid and liquid media demonstrated a high antimicrobial activity of the complexes against Gram-positive S. aureus but moderate against Gram-negative E. coli and C. albicans fungi |
dc.format.extent | 11 p. |
dc.language.iso | eng |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Spain |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
dc.subject | Àrees temàtiques de la UPC::Enginyeria dels materials::Materials plàstics i polímers |
dc.subject.lcsh | Polymers |
dc.subject.other | Comb-like polymer ionic complexes |
dc.subject.other | Hyaluronic acid |
dc.subject.other | Tetraalkylphosphonium surfactants |
dc.subject.other | Ionic polymer complexes |
dc.subject.other | Antimicrobial polymers |
dc.title | Amphiphilic ionic complexes of hyaluronic acid with organophosphonium compounds and their antimicrobial activity |
dc.type | Article |
dc.subject.lemac | Polímers |
dc.contributor.group | Universitat Politècnica de Catalunya. SUMMLab - Sustainability Measurement and Modeling Lab |
dc.contributor.group | Universitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics |
dc.identifier.doi | 10.1016/j.ijbiomac.2018.07.077 |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0141813018327491 |
dc.rights.access | Open Access |
local.identifier.drac | 23309886 |
dc.description.version | Postprint (updated version) |
local.citation.author | Gamarra, A.; Fores, E.; Morato, J.; Muñoz, S. |
local.citation.publicationName | International journal of biological macromolecules |
local.citation.volume | 118 |
local.citation.startingPage | 2021 |
local.citation.endingPage | 2031 |
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