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dc.contributor.authorGamarra Montes, Ana
dc.contributor.authorForés Gil, Eva
dc.contributor.authorMorató Farreras, Jordi
dc.contributor.authorMuñoz Guerra, Sebastián
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Òptica i Optometria
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.date.accessioned2019-04-30T11:14:27Z
dc.date.available2019-10-01T00:25:50Z
dc.date.issued2018-01-01
dc.identifier.citationGamarra, A. [et al.]. Amphiphilic ionic complexes of hyaluronic acid with organophosphonium compounds and their antimicrobial activity. "International journal of biological macromolecules", 1 Gener 2018, vol. 118, p. 2021-2031.
dc.identifier.issn0141-8130
dc.identifier.urihttp://hdl.handle.net/2117/132382
dc.description.abstractAmphiphilic ionic complexes of hyaluronic acid and alkyltrimethylphosphonium soaps with alkyl chains containing even numbers of carbons from 12 to 22 have been produced. The complexes have a nearly stoichiometric composition, are non-water soluble, and are stable to heat up to temperatures above 200¿°C. These complexes are amphiphilic and able to adopt a biphasic structure with the paraffinic and polysaccharide phases ordered arranged with a periodicity ranging between 3 and 5¿nm depending on n. The paraffinic phase in complexes with n¿=¿18 was crystallized and showed melting at temperatures between 58 and 70¿°C depending on the n value. The complexes decomposed upon incubation in water under physiological conditions, and undergone extensive biodegradation by the action of hyaluronidases. Biocide assays carried out in both solid and liquid media demonstrated a high antimicrobial activity of the complexes against Gram-positive S. aureus but moderate against Gram-negative E. coli and C. albicans fungi
dc.format.extent11 p.
dc.language.isoeng
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subjectÀrees temàtiques de la UPC::Enginyeria dels materials::Materials plàstics i polímers
dc.subject.lcshPolymers
dc.subject.otherComb-like polymer ionic complexes
dc.subject.otherHyaluronic acid
dc.subject.otherTetraalkylphosphonium surfactants
dc.subject.otherIonic polymer complexes
dc.subject.otherAntimicrobial polymers
dc.titleAmphiphilic ionic complexes of hyaluronic acid with organophosphonium compounds and their antimicrobial activity
dc.typeArticle
dc.subject.lemacPolímers
dc.contributor.groupUniversitat Politècnica de Catalunya. SUMMLab - Sustainability Measurement and Modeling Lab
dc.contributor.groupUniversitat Politècnica de Catalunya. POL - Polímers Industrials Avançats i Biopolímers Tecnològics
dc.identifier.doi10.1016/j.ijbiomac.2018.07.077
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0141813018327491
dc.rights.accessOpen Access
local.identifier.drac23309886
dc.description.versionPostprint (updated version)
local.citation.authorGamarra, A.; Fores, E.; Morato, J.; Muñoz, S.
local.citation.publicationNameInternational journal of biological macromolecules
local.citation.volume118
local.citation.startingPage2021
local.citation.endingPage2031


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