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dc.contributor.authorForns, Joan
dc.contributor.authorPottegard, Anton
dc.contributor.authorReinders, Tammo
dc.contributor.authorPoblador Plou, Beatriz
dc.contributor.authorMorros Padrós, Rosa
dc.contributor.authorBrandt, Lena
dc.contributor.authorCainzos Achirica, Miguel
dc.contributor.authorHellfritzsch, M
dc.contributor.authorSchink, Tania
dc.contributor.authorPrados Torres, Alexandra
dc.contributor.authorGiner Soriano, Maria
dc.contributor.authorHagg, David
dc.contributor.authorHallas, Jesper
dc.contributor.authorCortés Martínez, Jordi
dc.contributor.authorJacquot, Emmanuelle
dc.contributor.authorDeltour, Nicole
dc.contributor.authorPérez Gutthann, Susana
dc.contributor.authorPladevall, Miquel
dc.contributor.authorReutfors, Johan
dc.contributor.otherUniversitat Politècnica de Catalunya. Departament d'Estadística i Investigació Operativa
dc.date.accessioned2019-04-10T09:47:28Z
dc.date.available2019-04-10T09:47:28Z
dc.date.issued2019-04-15
dc.identifier.citationForns, J. [et al.]. Antidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: incidence and comorbidities of antidepressant initiators. "Journal of affective disorders", 15 Abril 2019, vol. 249, p. 242-252.
dc.identifier.issn0165-0327
dc.identifier.urihttp://hdl.handle.net/2117/131578
dc.description.abstractBackground We aimed to describe patterns of use and characteristics of 10 commonly used antidepressants for the period 2009–2014 in Denmark, Germany, Spain, and Sweden. Methods Adult initiators from 2009 to 2014 of each study antidepressant were identified in four countries using five data sources: the Danish National registers, GePaRD (Germany), EpiChron (Aragon, Spain), SIDIAP (Catalonia, Spain), and the Swedish National Registers. The study included 10 study antidepressants: citalopram, escitalopram, fluoxetine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, mirtazapine, and agomelatine. Results Citalopram was the most prescribed study antidepressant, followed by mirtazapine. Paroxetine and agomelatine were the least prescribed antidepressants. Mirtazapine was widely used among older antidepressant initiators with higher percentages of comorbidities at baseline, and fluoxetine was used among young patients. Citalopram and amitriptyline had the lowest percentage of multiple antidepressant use in the 12 months prior to the current treatment episode, while agomelatine, duloxetine, and venlafaxine had the highest percentage of multiple antidepressant use in the year prior to the current treatment episode. Limitations The most important limitations are exposure information based on filled prescriptions, focus on antidepressant initiators only, lack of information on the indication, and heterogeneity of the type of data across data sources. Conclusions Results of this study including 4.8 million study antidepressant initiators of study antidepressants suggest that citalopram and mirtazapine are the most commonly prescribed antidepressants. Agomelatine and paroxetine were the least used antidepressants in the participating populations. Mirtazapine was the antidepressant most commonly prescribed among older antidepressant initiators with high percentage of comorbidities at baseline, whereas fluoxetine was commonly used among young patients.
dc.format.extent11 p.
dc.language.isoeng
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Anàlisi multivariant
dc.subjectÀrees temàtiques de la UPC::Matemàtiques i estadística::Matemàtica aplicada a les ciències
dc.subject.lcshSampling (Statistics)
dc.subject.lcshBiology
dc.subject.otherAntidepressants
dc.subject.otherComorbidity
dc.subject.otherDrug utilization study
dc.subject.otherEurope
dc.titleAntidepressant use in Denmark, Germany, Spain, and Sweden between 2009 and 2014: incidence and comorbidities of antidepressant initiators
dc.typeArticle
dc.subject.lemacMostreig (Estadística)
dc.subject.lemacBiologia
dc.contributor.groupUniversitat Politècnica de Catalunya. GRBIO - Grup de Recerca en Bioestadística i Bioinformàtica
dc.identifier.doi10.1016/j.jad.2019.02.010
dc.description.peerreviewedPeer Reviewed
dc.subject.amsClassificació AMS::62 Statistics::62D05 Sampling theory, sample surveys
dc.subject.amsClassificació AMS::92 Biology and other natural sciences::92C Physiological, cellular and medical topics
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S016503271832398X
dc.rights.accessOpen Access
local.identifier.drac23941237
dc.description.versionPostprint (author's final draft)
local.citation.authorForns, J.; Pottegard, A.; Reinders, T.; Poblador, B.; Morros, R.; Brandt, L.; Cainzos, M.; Hellfritzsch, M.; Schink, T.; Prados-Torres, A.; Giner-Soriano, M.; Hagg, D.; Hallas, J.; Cortes, J.; Jacquot, E.; Deltour, N.; Pérez-Gutthann, S.; Pladevall, M.; Reutfors, J.
local.citation.publicationNameJournal of affective disorders
local.citation.volume249
local.citation.startingPage242
local.citation.endingPage252


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